METHODS: Four male patients presenting cryoglobulinemic vasculitis and who received DFPP sessions were included.
RESULTS: Their mean age was 57 ± 15 years. One patient had hepatitis-C virus (HCV)-related cryoglobulinemia and the other three patients were carriers of an IgM Kappa monoclonal gammopathy. Mean duration of follow-up was 15 ± 2 months. DFPP allowed healing of ulcerative skin lesions in the first patient and remission of nephrotic syndrome in the other patients after a median of 6(5-10) sessions.
CONCLUSIONS: DFPP can be used safely in cryoglobulinemic-vasculitis and can be considered early to achieve a faster and sustained clinical-biological response.
方法:纳入了4名出现冷球蛋白血症性血管炎并接受DFPP治疗的男性患者。
结果:他们的平均年龄为57±15岁。一名患者患有丙型肝炎病毒(HCV)相关的冷球蛋白血症,其他三名患者是IgMκ单克隆丙种球蛋白病的携带者。平均随访时间为15±2个月。在中位数为6(5-10)次之后,DFPP允许第一例患者的溃疡性皮肤病变愈合,其他患者的肾病综合征缓解。
结论:DFPP可以安全地用于冷球蛋白性血管炎,并且可以早期考虑实现更快和持续的临床生物学反应。