Abstract：
BACKGROUND: Paracoccidoidomycosis (PCM) is a granulomatous systemic mycosis endemic in southern Brazil.
OBJECTIVE: Analyze the clinical and epidemiological characteristics of cases of PCM with head and neck manifestations in southern Brazil.
METHODS: Retrospective study of histopathologically diagnosed cases of PCM with head and neck manifestations referred to two medical centers in the municipality of Santa Cruz do Sul, state of Rio Grande do Sul, Brazil, during a 10-year period (2011-2020).
RESULTS: Twenty-eight patients were selected. The number of cases usually ranged from one to four per year, although 11 cases were diagnosed in 2019. Most patients were between 40 and 59 years old. In total, 21 patients were men and seven were women (male:female ratio 3:1). Most (92%) were Caucasian and 46% were smokers. Patients were from 12 municipalities in the central-eastern region of the state. The most frequent site of the lesions was the larynx. Associated HIV and squamous cell carcinoma were both present in three cases.
CONCLUSIONS: This is the first study to analyze PCM cases from central-eastern Rio Grande do Sul. PCM is endemic in southern Brazil, and more epidemiological data are needed, considering that its incidence may be higher than currently estimated, as demonstrated by our results.
OBJECTIVE: Analyze the clinical and epidemiological characteristics of cases of PCM with head and neck manifestations in southern Brazil.
METHODS: Retrospective study of histopathologically diagnosed cases of PCM with head and neck manifestations referred to two medical centers in the municipality of Santa Cruz do Sul, state of Rio Grande do Sul, Brazil, during a 10-year period (2011-2020).
RESULTS: Twenty-eight patients were selected. The number of cases usually ranged from one to four per year, although 11 cases were diagnosed in 2019. Most patients were between 40 and 59 years old. In total, 21 patients were men and seven were women (male:female ratio 3:1). Most (92%) were Caucasian and 46% were smokers. Patients were from 12 municipalities in the central-eastern region of the state. The most frequent site of the lesions was the larynx. Associated HIV and squamous cell carcinoma were both present in three cases.
CONCLUSIONS: This is the first study to analyze PCM cases from central-eastern Rio Grande do Sul. PCM is endemic in southern Brazil, and more epidemiological data are needed, considering that its incidence may be higher than currently estimated, as demonstrated by our results.
摘要：
背景：副角菌病（PCM）是巴西南部的一种肉芽肿性全身性真菌病。
目的：分析巴西南部伴有头颈部表现的PCM病例的临床和流行病学特征。
方法：回顾性研究组织病理学诊断为头颈部表现的PCM病例，转诊至南圣克鲁斯市的两个医疗中心，南里奥格兰德州,巴西,在10年期间（2011-2020年）。
结果：选择28例患者。每年的病例数通常为1至4例,尽管2019年诊断出11例。大多数患者年龄在40至59岁之间。总的来说,21名患者为男性,7名为女性(男性:女性比例为3:1)。大多数（92％）是白种人，46％是吸烟者。患者来自该州中东部地区的12个城市。病变最常见的部位是喉。三例病例中均存在相关的HIV和鳞状细胞癌。
结论：这是第一个分析南里奥格兰德州中东部PCM病例的研究。PCM在巴西南部很流行,需要更多的流行病学数据，考虑到其发病率可能高于目前的估计，正如我们的结果所证明的。
目的：分析巴西南部伴有头颈部表现的PCM病例的临床和流行病学特征。
方法：回顾性研究组织病理学诊断为头颈部表现的PCM病例，转诊至南圣克鲁斯市的两个医疗中心，南里奥格兰德州,巴西,在10年期间（2011-2020年）。
结果：选择28例患者。每年的病例数通常为1至4例,尽管2019年诊断出11例。大多数患者年龄在40至59岁之间。总的来说,21名患者为男性,7名为女性(男性:女性比例为3:1)。大多数（92％）是白种人，46％是吸烟者。患者来自该州中东部地区的12个城市。病变最常见的部位是喉。三例病例中均存在相关的HIV和鳞状细胞癌。
结论：这是第一个分析南里奥格兰德州中东部PCM病例的研究。PCM在巴西南部很流行,需要更多的流行病学数据，考虑到其发病率可能高于目前的估计，正如我们的结果所证明的。
