Abstract：
Background: While the promotion of the beneficial effects of melatonin (MEL) ingestion on the modulation of oxidative stress is widespread, less attention is given to the biological influence that it could exert on the results of hematology and clinical chemistry parameters. This study was undertaken to assess the effects of acute MEL ingestion on these parameters during a maximal running exercise. Methods: In double blind randomized design, 12 professional soccer players [age: 17.54 ± 0.78 yrs, body mass: 70.31 ± 3.86 kg, body height: 1.8 ± 0.08 m; maximal aerobic speed (MAS): 16.85 ± 0.63 km/h; mean ± standard deviation], all males, performed a diurnal (17:00 h ± 30 h) running exercise test (RET) at 100% of their MAS following either MEL or placebo ingestion. Blood samples were obtained at rest and following the RET. Results: Compared to placebo, MEL intake decreased post-exercise biomarkers of liver damage (aspartate aminotransferase, p<0.001; alanine aminotransferase, p<0.001; gamma-glutamyltransferase; p<0.05) and improved post-exercise renal function markers (i.e., creatinine, p<0.001). However, lipid profile, glucose, lactate and leukocyte were not affected by MEL ingestion. Regarding the time to exhaustion, no difference was found between MEL (362.46 ± 42.06 s) and PLA (374.54 ± 57.97 s) conditions. Conclusion: The results of this investigation clearly attest that MEL ingestion before a maximal running exercise might protect athletes from liver damage and perturbation in renal function biomarkers. However, this study comprises an acute MEL supplementation and no assessment on chronic effects or circadian rhythm the day before was done.
摘要：
背景：虽然褪黑素（MEL）摄入对氧化应激调节的有益作用的促进是广泛的，较少关注它可能对血液学和临床化学参数结果产生的生物学影响。进行这项研究是为了评估在最大程度的跑步运动中急性MEL摄入对这些参数的影响。方法：采用双盲随机设计，12名职业足球运动员[年龄：17.54±0.78岁，体重：70.31±3.86公斤，身高：1.8±0.08m；最大有氧速度（MAS）：16.85±0.63km/h；平均值±标准偏差]，所有雄性,在服用MEL或安慰剂后，在100％的MAS进行了昼夜（17:00h±30h）跑步运动测试（RET）。在休息时和在RET之后获得血液样品。结果：与安慰剂相比，MEL摄入量减少运动后肝损伤的生物标志物（天冬氨酸转氨酶，p<0.001；丙氨酸转氨酶，p<0.001；γ-谷氨酰转移酶；p<0.05）和改善的运动后肾功能标志物（即肌酐,p<0.001)。然而,血脂谱,葡萄糖，乳酸和白细胞不受MEL摄入的影响。关于疲惫的时间，MEL(362.46±42.06s)和PLA(374.54±57.97s)条件无差异。结论：这项研究的结果清楚地证明，在最大程度的跑步运动之前摄入MEL可能会保护运动员免受肝脏损害和肾功能生物标志物的干扰。然而,本研究包括急性MEL补充剂,且未在前一天对慢性效应或昼夜节律进行评估.
