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Abstract：
Background Developmental delay refers to the insufficient acquisition of age-appropriate developmental milestones. According to World Health Organization, approximately 5% of all children under the age of 14 years display some developmental disability. Aim and objective Our objective was to investigate the prevalence of abnormal magnetic resonance imaging (MRI) brain findings in pediatric patients with non-syndromic developmental delay and to establish the utility of MRI for the same. Material and Method This cross-sectional study prospectively enrolled 60 pediatric patients (three months to 12 years) and data were analyzed using SPSS software. Result Abnormalities on MRI were seen in 80% of cases, with findings indicating perinatal hypoxic insult (36.67%) being the most common, followed by structural abnormalities of the brain (20%). There was no significant difference in the prevalence of abnormal findings when classified by gender or age, or between global developmental delay (GDD) alone and GDD with epilepsy. However, perinatal hypoxic insult was significantly associated with GDD with epilepsy rather than GDD alone (p < 0.01). Conclusion In this study, brain MRI provides a high yield of abnormal findings and helps calculate the relative prevalence of various common etiologies in non-syndromic developmental delay. This study supports several international guidelines that include MRI as the first-line investigation for non-syndromic developmental delay.
摘要：
背景发展延迟是指对适合年龄的发展里程碑的获取不足。根据世界卫生组织，所有14岁以下的儿童中约有5％表现出一定的发育障碍。目的和目的我们的目的是调查非综合征性发育迟缓的儿科患者的异常磁共振成像（MRI）脑部发现的患病率，并建立MRI的实用性。材料与方法本横断面研究前瞻性纳入60例儿科患者（3个月至12年），并使用SPSS软件对数据进行分析。结果80％的病例出现MRI异常，结果表明，围产期缺氧损伤（36.67％）是最常见的，其次是大脑结构异常(20%)。按性别或年龄分类时，异常发现的患病率没有显着差异，或单独的全球发育迟缓（GDD）和GDD伴癫痫。然而,围产期缺氧性损伤与GDD伴癫痫显著相关，而不是单独GDD(p<0.01)。结论在本研究中,脑部MRI提供了大量的异常发现，并有助于计算非综合征性发育迟缓中各种常见病因的相对患病率。这项研究支持一些国际指南，包括MRI作为非综合征性发育迟缓的一线研究。
