PDF(Pubmed)
Abstract：
UNASSIGNED: Recently, a new automated software (Heart Model) was developed to obtain three-dimensional (3D) left heart chamber volumes. The aim of this study was to verify the feasibility and accuracy of the automated 3D echocardiographic algorithm in heart transplant (HTx) patients. Conventional manual 3D transthoracic echocardiographic (TTE) tracings and cardiac magnetic resonance (CMR) images were used as a reference for comparison.
UNASSIGNED: This study enrolled 103 healthy HTx patients prospectively. In protocol 1, left ventricular end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), left atrial max volume (LAVmax), LA minimum volume (LAVmin) and LV ejection fraction (LVEF) were obtained using the automated 3D echocardiography (3DE) and compared with corresponding values obtained through the manual 3DE. In protocol 2, 28 patients\' automated 3DE measurements were compared with CMR reference values. The impacts of contour edit and surgical technique were also tested.
UNASSIGNED: Heart Model was feasible in 97.1% of the data sets. In protocol 1, there was strong correlation between 3DE and manual 3DE for all the parameters (r = 0.77 to 0.96, p<0.01). Compared to values obtained through manual measurements, LV volumes and LVEF were overestimated by the automated algorithm and LA volumes were underestimated. All the biases were small except for that of LAVmin. After contour adjustment, the biases reduced and all the limits of agreement were clinically acceptable. In protocol 2, the correlations for LV and LA volumes were strong between automated 3DE with contour edit and CMR (r = 0.74 to 0.93, p<0.01) but correlation for LVEF remained moderate (r = 0.65, p < 0.01). Automated 3DE overestimated LV volumes but underestimated LVEF and LA volumes compared with CMR. The limits of agreement were clinically acceptable only for LVEDV and LAVmax.
UNASSIGNED: Simultaneous quantification of left heart volumes and LVEF with the automated Heart Model program is rapid, feasible and to a great degree it is accurate in HTx recipients. Nevertheless, only LVEDV and LAVmax measured by automated 3DE with contour edit seem applicable for clinical practice when compared with CMR. Automated 3DE for HTx recipients is a worthy attempt, though further verification and optimization are needed.
UNASSIGNED: This study enrolled 103 healthy HTx patients prospectively. In protocol 1, left ventricular end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), left atrial max volume (LAVmax), LA minimum volume (LAVmin) and LV ejection fraction (LVEF) were obtained using the automated 3D echocardiography (3DE) and compared with corresponding values obtained through the manual 3DE. In protocol 2, 28 patients\' automated 3DE measurements were compared with CMR reference values. The impacts of contour edit and surgical technique were also tested.
UNASSIGNED: Heart Model was feasible in 97.1% of the data sets. In protocol 1, there was strong correlation between 3DE and manual 3DE for all the parameters (r = 0.77 to 0.96, p<0.01). Compared to values obtained through manual measurements, LV volumes and LVEF were overestimated by the automated algorithm and LA volumes were underestimated. All the biases were small except for that of LAVmin. After contour adjustment, the biases reduced and all the limits of agreement were clinically acceptable. In protocol 2, the correlations for LV and LA volumes were strong between automated 3DE with contour edit and CMR (r = 0.74 to 0.93, p<0.01) but correlation for LVEF remained moderate (r = 0.65, p < 0.01). Automated 3DE overestimated LV volumes but underestimated LVEF and LA volumes compared with CMR. The limits of agreement were clinically acceptable only for LVEDV and LAVmax.
UNASSIGNED: Simultaneous quantification of left heart volumes and LVEF with the automated Heart Model program is rapid, feasible and to a great degree it is accurate in HTx recipients. Nevertheless, only LVEDV and LAVmax measured by automated 3DE with contour edit seem applicable for clinical practice when compared with CMR. Automated 3DE for HTx recipients is a worthy attempt, though further verification and optimization are needed.
摘要：
未经批准：最近，开发了一种新的自动化软件(心脏模型)来获得三维(3D)左心室容积.这项研究的目的是验证自动3D超声心动图算法在心脏移植（HTx）患者中的可行性和准确性。使用常规的手动3D经胸超声心动图（TTE）描记和心脏磁共振（CMR）图像作为比较参考。
未经评估：本研究前瞻性招募了103名健康HTx患者。在方案1中，左心室舒张末期容积（LVEDV），左心室收缩末期容积(LVESV),左心房最大容积(LAVmax),使用自动3D超声心动图（3DE）获得LA最小体积（LAVmin）和LV射血分数（LVEF），并与通过手动3DE获得的相应值进行比较。在方案2中，将28名患者的自动3DE测量值与CMR参考值进行了比较。还测试了轮廓编辑和手术技术的影响。
UNASSIGNED：心脏模型在97.1%的数据集中是可行的。在方案1中,对于所有参数,3DE和手动3DE之间存在强相关性(r=0.77至0.96,p<0.01)。与通过手动测量获得的值相比，自动算法高估了LV体积和LVEF，低估了LA体积。除LAVmin外，所有偏差都很小。轮廓调整后，偏差减少,所有一致限度均为临床可接受.在方案2中，带轮廓编辑的自动3DE和CMR之间LV和LA体积的相关性很强（r=0.74至0.93，p<0.01），但LVEF的相关性仍然中等（r=0.65，p<0.01）。与CMR相比，自动3DE高估了LV体积，但低估了LVEF和LA体积。仅对于LVEDV和LAVmax，协议的界限在临床上是可接受的。
UNASSIGNED：使用自动心脏模型程序同时定量左心容积和LVEF是快速的，这是可行的，并且在很大程度上对HTX接收者是准确的。然而，与CMR相比，只有通过带有轮廓编辑的自动3DE测量的LVEDV和LAVmax似乎适用于临床实践。HTx收件人的自动化3DE是一个值得的尝试，尽管需要进一步的验证和优化。
未经评估：本研究前瞻性招募了103名健康HTx患者。在方案1中，左心室舒张末期容积（LVEDV），左心室收缩末期容积(LVESV),左心房最大容积(LAVmax),使用自动3D超声心动图（3DE）获得LA最小体积（LAVmin）和LV射血分数（LVEF），并与通过手动3DE获得的相应值进行比较。在方案2中，将28名患者的自动3DE测量值与CMR参考值进行了比较。还测试了轮廓编辑和手术技术的影响。
UNASSIGNED：心脏模型在97.1%的数据集中是可行的。在方案1中,对于所有参数,3DE和手动3DE之间存在强相关性(r=0.77至0.96,p<0.01)。与通过手动测量获得的值相比，自动算法高估了LV体积和LVEF，低估了LA体积。除LAVmin外，所有偏差都很小。轮廓调整后，偏差减少,所有一致限度均为临床可接受.在方案2中，带轮廓编辑的自动3DE和CMR之间LV和LA体积的相关性很强（r=0.74至0.93，p<0.01），但LVEF的相关性仍然中等（r=0.65，p<0.01）。与CMR相比，自动3DE高估了LV体积，但低估了LVEF和LA体积。仅对于LVEDV和LAVmax，协议的界限在临床上是可接受的。
UNASSIGNED：使用自动心脏模型程序同时定量左心容积和LVEF是快速的，这是可行的，并且在很大程度上对HTX接收者是准确的。然而，与CMR相比，只有通过带有轮廓编辑的自动3DE测量的LVEDV和LAVmax似乎适用于临床实践。HTx收件人的自动化3DE是一个值得的尝试，尽管需要进一步的验证和优化。
