Abstract:
Social-cognitive processes facilitate the use of environmental cues to understand others, and to be understood by others. Animal models provide vital insights into the neural underpinning of social behaviours. To understand social cognition at even deeper behavioural, cognitive, neural, and molecular levels, we need to develop more representative study models, which allow testing of novel hypotheses using human-relevant cognitive tasks. Due to their cooperative breeding system and relatively small size, common marmosets (Callithrix jacchus) offer a promising translational model for such endeavours. In addition to having social behavioural patterns and group dynamics analogous to those of humans, marmosets have cortical brain areas relevant for the mechanistic analysis of human social cognition, albeit in simplified form. Thus, they are likely suitable animal models for deciphering the physiological processes, connectivity and molecular mechanisms supporting advanced cognitive functions. Here, we review findings emerging from marmoset social and behavioural studies, which have already provided significant insights into executive, motivational, social, and emotional dysfunction associated with neurological and psychiatric disorders.
摘要:
社会认知过程有助于使用环境线索来理解他人,并被他人理解。动物模型为社会行为的神经基础提供了重要的见解。要在更深层次的行为上理解社会认知,认知,神经,和分子水平,我们需要开发更有代表性的学习模式,这允许使用人类相关的认知任务来测试新的假设。由于他们的合作育种系统和相对较小的规模,普通marmosets(Callithrixjacchus)为这种努力提供了一个有前途的平移模型。除了具有类似于人类的社会行为模式和群体动态之外,猿猴具有与人类社会认知机理分析相关的大脑皮层区域,尽管是简化的形式。因此,它们可能是破译生理过程的合适动物模型,支持高级认知功能的连通性和分子机制。这里,我们回顾了Marmoset社会和行为研究的发现,它们已经为高管提供了重要的见解,动机,社会,与神经和精神疾病相关的情绪功能障碍。