Abstract：
OBJECTIVE: This study aims at evaluating the non-invasive Magnetic Resonance Imaging (MRI) technic to visualize a synthetic composite hernia mesh using a rodent model and to document the integration of this device over 4 months.
METHODS: Uncoated polyethylene terephthalate mesh and synthetic composite mesh-faced on the visceral side with a chemically engineered layer of copolymer of glycolide, caprolactone, trimethylene carbonate, and lactide to minimize tissue attachment-were placed intraperitoneally in rats, facing the caecum previously scraped to promote petechial bleeding and subsequent adhesions. Meshes fate follow-up was performed 4, 10, and 16-weeks post-implantation using a rodent dedicated high field MRI. Magnetization transfer (MT) images were acquired, associated with pneumoperitonealMRI performed after intraperitoneal injection of 8 mL gas to induce mechanical stress on the abdominal wall.
RESULTS: Uncoated meshes were clearly visible using both T2-weighted and MT imaging during the whole study while composite meshes conspicuity was not so evident on T2-weighted MRI and could be improved using MT imaging. Adhesions and collagen infiltration were massive for the uncoated meshes as expected. On the contrary, composite meshes showed very limited adhesion, and, if any, occurring at the edge of the mesh, starting at the fixation points.
CONCLUSIONS: Magnetization transfer imaging allows to detect mesh integration and, associated with pneumoperitoneum, was able to probe the effective minimizing effect of the synthetic polymeric barrier on visceral attachments. However, magnetization transfer imaging could not unambiguously allow the visualization of the mesh through the polymeric barrier.
METHODS: Uncoated polyethylene terephthalate mesh and synthetic composite mesh-faced on the visceral side with a chemically engineered layer of copolymer of glycolide, caprolactone, trimethylene carbonate, and lactide to minimize tissue attachment-were placed intraperitoneally in rats, facing the caecum previously scraped to promote petechial bleeding and subsequent adhesions. Meshes fate follow-up was performed 4, 10, and 16-weeks post-implantation using a rodent dedicated high field MRI. Magnetization transfer (MT) images were acquired, associated with pneumoperitonealMRI performed after intraperitoneal injection of 8 mL gas to induce mechanical stress on the abdominal wall.
RESULTS: Uncoated meshes were clearly visible using both T2-weighted and MT imaging during the whole study while composite meshes conspicuity was not so evident on T2-weighted MRI and could be improved using MT imaging. Adhesions and collagen infiltration were massive for the uncoated meshes as expected. On the contrary, composite meshes showed very limited adhesion, and, if any, occurring at the edge of the mesh, starting at the fixation points.
CONCLUSIONS: Magnetization transfer imaging allows to detect mesh integration and, associated with pneumoperitoneum, was able to probe the effective minimizing effect of the synthetic polymeric barrier on visceral attachments. However, magnetization transfer imaging could not unambiguously allow the visualization of the mesh through the polymeric barrier.
摘要：
目的：本研究旨在评估非侵入性磁共振成像（MRI）技术，以使用啮齿动物模型可视化合成复合疝网片，并记录该设备在4个月内的集成。
方法：未涂覆的聚对苯二甲酸乙二醇酯网状物和合成的复合网状物-在内脏侧带有乙交酯共聚物的化学工程层，己内酯,三亚甲基碳酸酯,和丙交酯，以尽量减少组织附着-放置在大鼠腹膜内，面对先前刮擦的盲肠，以促进瘀斑出血和随后的粘连。植入后4、10和16周，使用啮齿动物专用高场MRI进行Meshes命运随访。获取磁化转移(MT)图像，与腹膜内注射8mL气体以引起腹壁机械应力后进行的气腹MRI相关。
结果：在整个研究过程中，使用T2加权和MT成像可以清楚地看到未涂覆的网格，而在T2加权MRI上复合网格的显著性并不那么明显，可以使用MT成像来改善。如预期的,对于未涂覆的网状物,粘附和胶原浸润是大量的。相反,复合网格显示出非常有限的附着力，and,如果有的话,发生在网格的边缘，从固定点开始。
结论：磁化转移成像允许检测网格集成，与气腹有关，能够探索合成聚合物屏障对内脏附着的有效最小化效果。然而,磁化转移成像不能明确地允许通过聚合物屏障的网格的可视化。
方法：未涂覆的聚对苯二甲酸乙二醇酯网状物和合成的复合网状物-在内脏侧带有乙交酯共聚物的化学工程层，己内酯,三亚甲基碳酸酯,和丙交酯，以尽量减少组织附着-放置在大鼠腹膜内，面对先前刮擦的盲肠，以促进瘀斑出血和随后的粘连。植入后4、10和16周，使用啮齿动物专用高场MRI进行Meshes命运随访。获取磁化转移(MT)图像，与腹膜内注射8mL气体以引起腹壁机械应力后进行的气腹MRI相关。
结果：在整个研究过程中，使用T2加权和MT成像可以清楚地看到未涂覆的网格，而在T2加权MRI上复合网格的显著性并不那么明显，可以使用MT成像来改善。如预期的,对于未涂覆的网状物,粘附和胶原浸润是大量的。相反,复合网格显示出非常有限的附着力，and,如果有的话,发生在网格的边缘，从固定点开始。
结论：磁化转移成像允许检测网格集成，与气腹有关，能够探索合成聚合物屏障对内脏附着的有效最小化效果。然而,磁化转移成像不能明确地允许通过聚合物屏障的网格的可视化。
