PDF(Pubmed)
Abstract：
UNASSIGNED: There were no reports on the associations of aortic arch calcification (AAC) measured by chest X-ray with all-cause mortality and cardiovascular disease (CVD) in older general population. Moreover, previous studies of hemodialysis patients showed that AAC was correlated with left ventricular hypertrophy (LVH) and predicted CVD jointly. Whether the effects remained in the general population is unknown. We examined the associations of AAC with all-cause mortality and CVD in general population and the risk associated with the coexistence of AAC and LVH.
UNASSIGNED: Presence and severity (grades 0-2) of AAC were measured by chest X-ray, and LVH was identified by 12-lead electrocardiogram in 27,166 Chinese aged 50+ years free of CVD from Guangzhou Biobank Cohort Study. Multivariate Cox regressions were used to examine associations of AAC and LVH with outcomes.
UNASSIGNED: During an average follow-up of 14·3 years, 5,350 deaths and 4,012 CVD occurred. Compared to those without AAC at baseline, those with AAC had higher risks of all-cause mortality (HR 1·24, 95% CI 1·17-1·31) and CVD (HR 1·22, 95% CI 1·14-1·30), with dose-response relationship (P ≤ 0·001). Furthermore, those with coexistence of AAC and LVH had higher risks of all-cause mortality (HR 1·72, 95% CI 1·37-2·15) and CVD (HR 1·80, 95% CI 1·40-2·32) than those without AAC and LVH.
UNASSIGNED: As chest X-ray has been performed commonly for health screening and in hospital patients when first admitted, AAC measured by chest X-ray can be further applied to assist cardiovascular risk stratification in the community and clinical settings.
UNASSIGNED: The Natural Science Foundation of China (No. 81941019).
UNASSIGNED: Presence and severity (grades 0-2) of AAC were measured by chest X-ray, and LVH was identified by 12-lead electrocardiogram in 27,166 Chinese aged 50+ years free of CVD from Guangzhou Biobank Cohort Study. Multivariate Cox regressions were used to examine associations of AAC and LVH with outcomes.
UNASSIGNED: During an average follow-up of 14·3 years, 5,350 deaths and 4,012 CVD occurred. Compared to those without AAC at baseline, those with AAC had higher risks of all-cause mortality (HR 1·24, 95% CI 1·17-1·31) and CVD (HR 1·22, 95% CI 1·14-1·30), with dose-response relationship (P ≤ 0·001). Furthermore, those with coexistence of AAC and LVH had higher risks of all-cause mortality (HR 1·72, 95% CI 1·37-2·15) and CVD (HR 1·80, 95% CI 1·40-2·32) than those without AAC and LVH.
UNASSIGNED: As chest X-ray has been performed commonly for health screening and in hospital patients when first admitted, AAC measured by chest X-ray can be further applied to assist cardiovascular risk stratification in the community and clinical settings.
UNASSIGNED: The Natural Science Foundation of China (No. 81941019).
摘要：
UNASSIGNED：在老年普通人群中，没有通过胸部X线测量的主动脉弓钙化（AAC）与全因死亡率和心血管疾病（CVD）相关的报道。此外，先前对血液透析患者的研究表明，AAC与左心室肥厚（LVH）和预测的CVD共同相关。在普通人群中是否仍然存在影响尚不清楚。我们研究了一般人群中AAC与全因死亡率和CVD的关系，以及与AAC和LVH共存相关的风险。
未经评估：通过胸部X线测量AAC的存在和严重程度（0-2级），根据广州生物库队列研究，在27,166名50岁以上无心血管疾病的中国人中，通过12导联心电图确定了LVH。多变量Cox回归用于检查AAC和LVH与结果的关联。
未经评估：在平均14·3年的随访中，发生5,350例死亡和4,012例CVD。与基线时没有AAC的相比，AAC患者的全因死亡率(HR1·24，95%CI1·17-1·31)和CVD(HR1·22，95%CI1·14-1·30)风险较高，呈剂量-反应关系（P≤0·001）。此外，与没有AAC和LVH的患者相比,AAC和LVH共存的患者发生全因死亡率(HR1·72,95%CI1·37-2·15)和CVD(HR1·80,95%CI1·40-2·32)的风险更高.
未经评估：由于胸部X线检查通常用于健康筛查，并且在首次入院时也用于住院患者，通过胸部X射线测量的AAC可以进一步应用于辅助社区和临床环境中的心血管风险分层。
联合国：中国自然科学基金（编号：81941019)。
未经评估：通过胸部X线测量AAC的存在和严重程度（0-2级），根据广州生物库队列研究，在27,166名50岁以上无心血管疾病的中国人中，通过12导联心电图确定了LVH。多变量Cox回归用于检查AAC和LVH与结果的关联。
未经评估：在平均14·3年的随访中，发生5,350例死亡和4,012例CVD。与基线时没有AAC的相比，AAC患者的全因死亡率(HR1·24，95%CI1·17-1·31)和CVD(HR1·22，95%CI1·14-1·30)风险较高，呈剂量-反应关系（P≤0·001）。此外，与没有AAC和LVH的患者相比,AAC和LVH共存的患者发生全因死亡率(HR1·72,95%CI1·37-2·15)和CVD(HR1·80,95%CI1·40-2·32)的风险更高.
未经评估：由于胸部X线检查通常用于健康筛查，并且在首次入院时也用于住院患者，通过胸部X射线测量的AAC可以进一步应用于辅助社区和临床环境中的心血管风险分层。
联合国：中国自然科学基金（编号：81941019)。
