Abstract：
Cutaneous adnexal tumours (ATs) encompass a variegated group of hamartomas and benign or malignant tumours, originating from the hair follicle, sebaceous, eccrine or apocrine glands that may simulate other cutaneous neoplasms. This study aims to provide a comprehensive overview of the spectrum of clinical and dermoscopic features of ATs, to better define these lesions and assist in the differential diagnosis. We performed a two-step systematic search of the literature in PubMed, Embase and Cochrane Library databases from inception until 4 September 2020. In the first step, we aimed to define histological variants of ATs with descriptions of dermoscopic criteria. The second step included a search for the name of each previously identified AT variants in the same databases adding \'AND (epilum* or dermosc* or dermatosc*)\'. All study types in English language reporting dermoscopic images of ATs were included. Collisions between ATs and other inflammatory or neoplastic skin lesions were excluded, with the exception of collisions with a sebaceous nevus. The protocol of this study was prospectively registered in PROSPERO (CRD42021244677). In total, 206 articles met our inclusion criteria, encompassing 372 ATs in 365 patients. Most ATs were apocrine-eccrine (n = 217, 58.3%, n = 173 benign) with a prevalence of poromas (n = 82), followed by follicular ATs (n = 88, 23.7%, n = 83 benign) and sebaceous ATs (n = 67, 18.0%, n = 49 benign). Most patients had a single AT lesion (320, 86.0%), while 42 (11.3%) had multiple ATs. A syndrome causing multiple ATs was identified in 15 patients. Histopathological analysis revealed 82% benign (n = 305) and 18.0% malignant (n = 67). ATs were classified according to their ability to mimic four groups of more common skin tumours: basal cell carcinoma, squamous cell carcinoma, melanocytic lesions and benign cutaneous lesions. Moreover, we have highlighted the ability of malignant variants of ATs to simulate benign skin lesions. This systematic review offers a comprehensive overview of the common clinical and dermoscopic features of follicular, sebaceous and apocrine-eccrine ATs and details possible differential dermoscopic features.
摘要：
皮肤附件肿瘤（ATs）包括杂色的错构瘤和良性或恶性肿瘤，起源于毛囊，皮脂腺,可以模拟其他皮肤肿瘤的内分泌或大汗腺。本研究旨在全面概述ATs的临床和皮肤镜特征，为了更好地定义这些病变并协助鉴别诊断。我们对PubMed中的文献进行了两步系统的搜索，Embase和Cochrane图书馆数据库从成立到2020年9月4日。第一步,我们旨在通过皮肤镜标准的描述来定义ATs的组织学变异。第二步包括在相同的数据库中搜索每个先前识别的AT变体的名称，并添加“AND（epilum*或dermosc*或deremosc*）”。包括英语报告的ATs皮肤镜图像的所有研究类型。ATs和其他炎性或肿瘤性皮肤病变之间的碰撞被排除，除了与皮脂腺痣的碰撞。本研究的方案在PROSPERO（CRD42021244677）中进行了前瞻性注册。总的来说,206篇文章符合我们的纳入标准，包括365名患者中的372名ATs。大多数AT是大分泌-小分泌(n=217，58.3%，n=173个良性），并伴有孔瘤（n=82），其次是卵泡性房性心动过速(n=88，23.7%，n=83良性)和皮脂腺房性心动过速(n=67，18.0%，n=49良性)。大多数患者有一个单一的AT病变（320，86.0％），而42人（11.3%）有多个ATs。在15例患者中发现了导致多个房性心动过速的综合征。组织病理学分析显示82％的良性（n=305）和18.0％的恶性（n=67）。ATs根据其模拟四组更常见皮肤肿瘤的能力进行分类：基底细胞癌，鳞状细胞癌,黑素细胞病变和良性皮肤病变。此外，我们强调了ATs恶性变种模拟良性皮肤病变的能力.本系统综述全面概述了卵泡的常见临床和皮肤镜特征，皮脂腺和大汗腺-内分泌AT，并详细介绍了可能的差异皮肤镜特征。
