癌细胞中 PD - L1 和 PD - L2 的产生 : 从核染色质重组到细胞外呈递。
关键词: 3′-UTR, 3′-untranslated region ADAM17, a disintegrin and metalloprotease 17 APCs, antigen-presenting cells AREs, adenylate and uridylate (AU)-rich elements ATF3, activating transcription factor 3 CD273/274, cluster of differentiation 273/274 CDK4, cyclin-dependent kinase 4 CMTM6, CKLF like MARVEL transmembrane domain containing 6 CSN5, COP9 signalosome subunit 5 CTLs, cytotoxic T lymphocytes EMT, epithelial to mesenchymal transition EpCAM, epithelial cell adhesion molecule Exosome FACS, fluorescence-activated cell sorting GSDMC, Gasdermin C GSK3β, glycogen synthase kinase 3 beta HSF1, heat shock transcription factor 1 Hi-C, high throughput chromosome conformation capture ICB, immune checkpoint blockade IFN, interferon IL-6, interleukin 6 IRF1, interferon regulatory factor 1 Immune checkpoint blockade JAK, Janus kinase 1 NFκB, nuclear factor kappa B NSCLC, non-small cell lung cancer OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1 PARP1, poly(ADP-ribose) polymerase 1 PD-1, programmed cell death-1 PD-L1 PD-L1, programmed death-ligand 1 PD-L2 PD-L2, programmed death ligand 2 Post-transcriptional regulation Post-translational regulation SP1, specificity protein 1 SPOP, speckle-type POZ protein STAG2, stromal antigen 2 STAT3, signal transducer and activator of transcription 3 T2D, type 2 diabetes TADs, topologically associating domains TFEB, transcription factor EB TFs, transcription factors TNFα, tumor necrosis factor-alpha TTP, tristetraprolin Topologically associating domain Transcription UCHL1, ubiquitin carboxy-terminal hydrolase L1 USP22, ubiquitin specific peptidase 22 dMMR, deficient DNA mismatch repair irAEs, immune related adverse events
来 源:
DOI:10.1016/j.apsb.2021.09.010
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