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Abstract：
Ovarian strumal carcinoid is a rare tumor in which thyroid (struma) and carcinoid components coexist. The disease is generally considered to be a borderline malignancy, however, cases with metastatic disease have been described. No data in the literature are available to guide diagnosis and therapy.
We performed a pooled analysis and a systematic review of histopathological-confirmed strumal carcinoid cases published in the literature using the following keywords: \"strumal carcinoid of the ovary\", \"strumal carcinoid case report\". A case of strumal carcinoid tumor diagnosed and followed-up at the Medical Oncology Unit of Spedali Civili (Brescia, Italy) was also described and included.
Sixty-six eligible publications were identified, providing data from one hundred and seventeen patients, plus a case diagnosed at our institution. At presentation, among the eighty-eight patients with symptomatic disease, 37% of patients suffered from abdominal distention and 49% from pain due to a growing abdominal tumor mass, 37% from constipation (peptide YY was analyzed in only nine of them, resulting above the physiologic range). Surgery was the primary therapy in 99% of the patients. Three patients had metastatic disease at diagnosis and five patients underwent recurrence after radical surgery. Histology at disease recurrence concerned the thyroid component in two patients, the carcinoid component in two patients, both histologies in one patient. Median disease-free survival and overall survival in this series were not attained.
Strumal carcinoid of the ovary generally presents a benign behavior and surgery is curative in most cases. However, a small group of patients with this disease can undergo disease recurrence due to both the thyroid and the neuroendocrine (carcinoid) components. A follow-up in radically operated patients is therefore needed, particularly in those with a voluminous disease at diagnosis.
We performed a pooled analysis and a systematic review of histopathological-confirmed strumal carcinoid cases published in the literature using the following keywords: \"strumal carcinoid of the ovary\", \"strumal carcinoid case report\". A case of strumal carcinoid tumor diagnosed and followed-up at the Medical Oncology Unit of Spedali Civili (Brescia, Italy) was also described and included.
Sixty-six eligible publications were identified, providing data from one hundred and seventeen patients, plus a case diagnosed at our institution. At presentation, among the eighty-eight patients with symptomatic disease, 37% of patients suffered from abdominal distention and 49% from pain due to a growing abdominal tumor mass, 37% from constipation (peptide YY was analyzed in only nine of them, resulting above the physiologic range). Surgery was the primary therapy in 99% of the patients. Three patients had metastatic disease at diagnosis and five patients underwent recurrence after radical surgery. Histology at disease recurrence concerned the thyroid component in two patients, the carcinoid component in two patients, both histologies in one patient. Median disease-free survival and overall survival in this series were not attained.
Strumal carcinoid of the ovary generally presents a benign behavior and surgery is curative in most cases. However, a small group of patients with this disease can undergo disease recurrence due to both the thyroid and the neuroendocrine (carcinoid) components. A follow-up in radically operated patients is therefore needed, particularly in those with a voluminous disease at diagnosis.
摘要：
卵巢类癌是一种罕见的肿瘤，其中甲状腺（甲状腺肿）和类癌成分共存。该疾病通常被认为是边缘性恶性肿瘤，然而,已经描述了转移性疾病的病例。文献中没有数据可用于指导诊断和治疗。
我们使用以下关键词对文献中发表的组织病理学证实的类癌病例进行了汇总分析和系统评价：“卵巢类癌”，“胸膜类癌病例报告”。在SpedaliCivili的肿瘤内科病房诊断并随访了一例树状类癌肿瘤（布雷西亚，意大利）也被描述和包括在内。
确定了66篇合格出版物，提供来自117名患者的数据，加上我们机构确诊的病例.在介绍时,在88名有症状的患者中，37％的患者患有腹胀，49％的患者因腹部肿瘤肿块增大而疼痛，37%来自便秘(仅在其中9个中分析了肽YY，导致高于生理范围)。手术是99%患者的主要治疗方法。3例患者在诊断时患有转移性疾病，5例患者在根治性手术后复发。疾病复发时的组织学与两名患者的甲状腺成分有关，两名患者的类癌成分，一名患者的两种组织学。未达到该系列中的中位无病生存期和总生存期。
卵巢类癌通常表现为良性行为，手术在大多数情况下是治愈性的。然而,由于甲状腺和神经内分泌（类癌）成分，一小部分患有这种疾病的患者可能会复发。因此，需要对彻底手术的患者进行随访，特别是那些在诊断时患有大量疾病的人。
我们使用以下关键词对文献中发表的组织病理学证实的类癌病例进行了汇总分析和系统评价：“卵巢类癌”，“胸膜类癌病例报告”。在SpedaliCivili的肿瘤内科病房诊断并随访了一例树状类癌肿瘤（布雷西亚，意大利）也被描述和包括在内。
确定了66篇合格出版物，提供来自117名患者的数据，加上我们机构确诊的病例.在介绍时,在88名有症状的患者中，37％的患者患有腹胀，49％的患者因腹部肿瘤肿块增大而疼痛，37%来自便秘(仅在其中9个中分析了肽YY，导致高于生理范围)。手术是99%患者的主要治疗方法。3例患者在诊断时患有转移性疾病，5例患者在根治性手术后复发。疾病复发时的组织学与两名患者的甲状腺成分有关，两名患者的类癌成分，一名患者的两种组织学。未达到该系列中的中位无病生存期和总生存期。
卵巢类癌通常表现为良性行为，手术在大多数情况下是治愈性的。然而,由于甲状腺和神经内分泌（类癌）成分，一小部分患有这种疾病的患者可能会复发。因此，需要对彻底手术的患者进行随访，特别是那些在诊断时患有大量疾病的人。
