Abstract：
BACKGROUND: In the blood vessels the impaired hemorheological parameters in patients with type 2 diabetes mellitus (T2DM) could lead to elevated flow resistance, increased forces at the endothelial wall and to microvascular disturbances.
OBJECTIVE: The aim of the study is to investigate the hemorheological variables and the changes of the skin blood flow responses to cold stress in T2DM patients.
METHODS: The basic hemorheological parameters: hematocrit (Ht), fibrinogen (Fib), whole blood viscosity (WBV) and plasma viscosity (PV) were examined in 20 patients with T2DM and a control group of 10 healthy age and sex matched controls. The mechanisms of vascular tone regulation were investigated using the wavelet analysis of the skin temperature oscillations (WAST). The degrees of the microvascular tone changes were determined during a cold test in the endothelial (0.02-0.0095 Hz), neurogenic (0.05- 0.02 Hz) and myogenic (0.05- 0.14 Hz) frequency ranges.
RESULTS: Significant increase of Fib and WBV in the patients in comparison to controls was found. The mean values of the amplitudes of the skin temperature (ST) pulsations decreased significantly during the cold stress only in the endothelial frequency range for the diabetic patients.
CONCLUSIONS: The results of our study reveal parallel impairment of the blood rheological parameters and the cutaneous microcirculation in T2DM patients.
OBJECTIVE: The aim of the study is to investigate the hemorheological variables and the changes of the skin blood flow responses to cold stress in T2DM patients.
METHODS: The basic hemorheological parameters: hematocrit (Ht), fibrinogen (Fib), whole blood viscosity (WBV) and plasma viscosity (PV) were examined in 20 patients with T2DM and a control group of 10 healthy age and sex matched controls. The mechanisms of vascular tone regulation were investigated using the wavelet analysis of the skin temperature oscillations (WAST). The degrees of the microvascular tone changes were determined during a cold test in the endothelial (0.02-0.0095 Hz), neurogenic (0.05- 0.02 Hz) and myogenic (0.05- 0.14 Hz) frequency ranges.
RESULTS: Significant increase of Fib and WBV in the patients in comparison to controls was found. The mean values of the amplitudes of the skin temperature (ST) pulsations decreased significantly during the cold stress only in the endothelial frequency range for the diabetic patients.
CONCLUSIONS: The results of our study reveal parallel impairment of the blood rheological parameters and the cutaneous microcirculation in T2DM patients.
摘要：
背景：在血管中，2型糖尿病（T2DM）患者的血液流变学参数受损可能导致血流阻力升高，内皮壁处的力增加和微血管紊乱。
目的：本研究的目的是研究2型糖尿病患者血液流变学变量和皮肤血流响应冷应激的变化。
方法：基本血液流变学参数：血细胞比容（Ht），纤维蛋白原（Fib），对20例T2DM患者和10例年龄和性别相匹配的健康对照组进行全血粘度（WBV）和血浆粘度（PV）检测。使用皮肤温度振荡（WAST）的小波分析研究了血管张力调节的机制。在内皮细胞的冷测试过程中确定微血管张力变化的程度（0.02-0.0095Hz），神经源性（0.05-0.02Hz）和肌源性（0.05-0.14Hz）频率范围。
结果：与对照组相比，患者的Fib和WBV显著增加。仅在糖尿病患者的内皮频率范围内，在冷应激期间，皮肤温度（ST）脉动幅度的平均值显着降低。
结论：我们的研究结果揭示了T2DM患者血液流变学参数和皮肤微循环的平行损害。
目的：本研究的目的是研究2型糖尿病患者血液流变学变量和皮肤血流响应冷应激的变化。
方法：基本血液流变学参数：血细胞比容（Ht），纤维蛋白原（Fib），对20例T2DM患者和10例年龄和性别相匹配的健康对照组进行全血粘度（WBV）和血浆粘度（PV）检测。使用皮肤温度振荡（WAST）的小波分析研究了血管张力调节的机制。在内皮细胞的冷测试过程中确定微血管张力变化的程度（0.02-0.0095Hz），神经源性（0.05-0.02Hz）和肌源性（0.05-0.14Hz）频率范围。
结果：与对照组相比，患者的Fib和WBV显著增加。仅在糖尿病患者的内皮频率范围内，在冷应激期间，皮肤温度（ST）脉动幅度的平均值显着降低。
结论：我们的研究结果揭示了T2DM患者血液流变学参数和皮肤微循环的平行损害。
