Abstract：
Neurogenic lower urinary tract dysfunction (NLUTD) is a common urological disease that causes long-term complications and severely reduces patient\'s quality of life. Sacral neuromodulation has proven to be an effective treatment for NLUTD. However, most previous studies have focused mainly on the efficacy and safety of sacral neuromodulation in the treatment of NLUTD and less on the changes in urodynamic parameters in patients before and after sacral neuromodulation. This study aimed to evaluate the effect of short-term sacral neuromodulation on the results of video-urodynamic parameters in a 63-year-old woman with NLUTD with vesicoureteral reflux. The patient was admitted to the Department of Urology of Beijing Hospital in January 2021 and examined using video-urodynamics. In the same month, the patient underwent the first stage of sacral neuromodulation, with an experience period of 2 weeks. After the experience period ended, video-urodynamics was performed again in February 2021. By comparing the two video-urodynamic results, the effect of short-term sacral neuromodulation on the anatomy and physiology of the lower urinary tract was determined. After 2 weeks of sacral neuromodulation treatment, video-urodynamic parameter analysis showed that while the urine storage period of the patient significantly improved, the voiding period was not significantly changed. This was specifically reflected in the improvement of bladder compliance, safe capacity of the bladder, and significant reduction in vesicoureteral reflux. The improvement of the safe capacity of the bladder effectively helped the patient to control the number of intermittent catheterizations within an acceptable range, which greatly improved her quality of life. Therefore, the patient underwent permanent sacral neuromodulation implantation in February 2021. This study suggests that short-term sacral neuromodulation can significantly improve lower urinary tract function and reduce vesicoureteral reflux in patients with NLUTD with vesicoureteral reflux. In short, we believe that sacral neuromodulation may be a good choice for patients with NLUTD.
摘要：
神经源性下尿路功能障碍(NLUTD)是一种常见的泌尿系疾病,可引起长期并发症,严重影响患者的生活质量。骶骨神经调节已被证明是NULTD的有效治疗方法。然而,以往的研究主要集中在骶神经调节治疗NULTD的疗效和安全性,较少关注骶神经调节前后患者尿动力学参数的变化.这项研究旨在评估短期骶神经调节对63岁女性膀胱输尿管反流NUTD患者视频尿动力学参数结果的影响。该患者于2021年1月入住北京医院泌尿外科，并使用视频尿动力学检查。同月,患者接受了第一阶段的骶神经调节，具有2周的经验期。体验期结束后,视频尿动力学在2021年2月再次进行。通过比较两种视频尿动力学结果，确定了短期骶神经调节对下尿路解剖和生理的影响。骶骨神经调节治疗2周后，视频尿动力学参数分析显示,患者的尿液贮存期明显改善,排尿期无明显变化。这特别反映在膀胱顺应性的改善上，膀胱的安全容量，膀胱输尿管反流显著减少。膀胱安全容量的提高有效地帮助患者将间歇性导尿次数控制在可接受范围内，这大大提高了她的生活质量。因此,患者于2021年2月接受了永久性骶骨神经调节植入术.这项研究表明，短期的骶神经调节可以显着改善NUTD伴膀胱输尿管反流的患者的下尿路功能并减少膀胱输尿管反流。总之,我们认为骶神经调节可能是NULTD患者的良好选择.
