Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report.

妊娠期抗 N - 甲基 - D - 天冬氨酸受体 (NMDAr) 脑炎 1 例.

• 发表时间: 2022
• 来源期刊: Epilepsy Behav Rep
• DOI: 10.1016/j.ebr.2022.100535
• PMID: 35520953
• 文章类型: Case Reports
• 作者列表: Dono F,Evangelista G,Consoli S,Scorrano G,Russo M,di Pietro M,Onofrj M,Sensi SL,Anzellotti F

关键词: Epilepsy; Fetal outcome; Lacosamide; Maternal outcome; Seizures

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of anti-NR1 antibodies through the placenta can be instrumental in the development of complications in newborns. We describe a case of a young woman suffering from anti-NMDAR encephalitis during the first trimester of pregnancy and focus on diagnostic and therapeutic management.

摘要

抗N-甲基-D-天冬氨酸受体（NMDAr）抗体脑炎是一种自身免疫性疾病，其特征是由于靶向NR1亚基的循环抗体导致NMDAr的突触活性降低。很少描述怀孕期间抗NMDAR脑炎的病例。抗NR1抗体通过胎盘的渗透可能有助于新生儿并发症的发展。我们描述了一名年轻女性在怀孕的前三个月患有抗NMDAR脑炎的病例，并专注于诊断和治疗管理。