PDF(Pubmed)
Abstract：
UNASSIGNED: Patients with psychiatric disorders are at an increased risk of developing cardiovascular disease, reducing life expectancy. Autonomic dysfunction has been linked to this increased risk; many studies have found reductions in heart rate variability (HRV). Only a few studies have systematically explored the relationship between obsessive-compulsive disorder (OCD) and autonomic function, and they have found contradicting results. The present study is intended to explore comprehensive autonomic functions in OCD patients and compare them with healthy controls.
UNASSIGNED: A total of 18 OCD patients meeting Diagnostic and Statistical Manual of Mental Disorders - 5 (DSM-5) criteria were enrolled to undergo comprehensive autonomic function testing, and the results were compared with 25 age- and sex-matched healthy controls.
UNASSIGNED: Time-domain parameters of HRV such as standard deviation of the RR intervals, coefficient of variance of RR intervals, standard deviation of differences between adjacent RR intervals, root square of the mean of the sum of the squares of differences between adjacent RR intervals, and percentage of number of RR interval differences ≥ 50 ms were significantly lower in OCD patients, indicating lesser parasympathetic tone. Frequency-domain parameters such as total power and very low frequency were significantly lower in OCD patients, indicating a significant decrease in autonomic tone. Nonlinear parameters such as dispersion of points perpendicular to the line of identity and dispersion of points along the line of identity were significantly lower in OCD patients, indicating altered vagal and sympathetic tone. In autonomic reactivity tests, the fall in systolic blood pressure during the lying to standing test and change in diastolic blood pressure during the cold pressor test were significantly altered in OCD patients, indicating abnormal sympathetic reactivity. There was no significant correlation between autonomic parameters and the severity of OCD.
UNASSIGNED: OCD is characterized by a decreased parasympathetic tone and abnormal sympathetic reactivity compared to normal controls.
UNASSIGNED: A total of 18 OCD patients meeting Diagnostic and Statistical Manual of Mental Disorders - 5 (DSM-5) criteria were enrolled to undergo comprehensive autonomic function testing, and the results were compared with 25 age- and sex-matched healthy controls.
UNASSIGNED: Time-domain parameters of HRV such as standard deviation of the RR intervals, coefficient of variance of RR intervals, standard deviation of differences between adjacent RR intervals, root square of the mean of the sum of the squares of differences between adjacent RR intervals, and percentage of number of RR interval differences ≥ 50 ms were significantly lower in OCD patients, indicating lesser parasympathetic tone. Frequency-domain parameters such as total power and very low frequency were significantly lower in OCD patients, indicating a significant decrease in autonomic tone. Nonlinear parameters such as dispersion of points perpendicular to the line of identity and dispersion of points along the line of identity were significantly lower in OCD patients, indicating altered vagal and sympathetic tone. In autonomic reactivity tests, the fall in systolic blood pressure during the lying to standing test and change in diastolic blood pressure during the cold pressor test were significantly altered in OCD patients, indicating abnormal sympathetic reactivity. There was no significant correlation between autonomic parameters and the severity of OCD.
UNASSIGNED: OCD is characterized by a decreased parasympathetic tone and abnormal sympathetic reactivity compared to normal controls.
摘要：
未经证实：患有精神疾病的患者患心血管疾病的风险增加，减少预期寿命。自主神经功能障碍与这种风险增加有关；许多研究发现心率变异性（HRV）降低。只有少数研究系统地探讨了强迫症(OCD)与自主神经功能的关系,他们发现了矛盾的结果。本研究旨在探讨强迫症患者的综合自主神经功能，并将其与健康对照进行比较。
UNASSIGNED：共有18名符合精神障碍诊断和统计手册-5（DSM-5）标准的强迫症患者被纳入全面的自主神经功能测试，并将结果与25名年龄和性别匹配的健康对照进行比较。
UNASSIGNED：HRV的时域参数，例如RR间隔的标准偏差，RR间隔的变异系数，相邻RR间隔之间差异的标准偏差，相邻RR间隔之间的差的平方和的平均值的平方根，OCD患者RR间期差异≥50ms的数量百分比显着降低，表明副交感神经张力较小。OCD患者的总功率和极低频等频域参数明显较低，表明自主神经音显著下降。OCD患者的非线性参数如垂直于同一性线的点的分散和沿同一性线的点的分散显著降低，表明迷走神经和交感神经张力改变。在自主反应性测试中，强迫症患者在躺到站立测试期间的收缩压下降和在冷加压测试期间的舒张压变化显着改变，表明交感神经反应异常。自主神经参数与强迫症的严重程度之间没有显着相关性。
UNASSIGNED：强迫症的特征是与正常对照组相比，副交感神经张力降低和交感神经反应异常。
UNASSIGNED：共有18名符合精神障碍诊断和统计手册-5（DSM-5）标准的强迫症患者被纳入全面的自主神经功能测试，并将结果与25名年龄和性别匹配的健康对照进行比较。
UNASSIGNED：HRV的时域参数，例如RR间隔的标准偏差，RR间隔的变异系数，相邻RR间隔之间差异的标准偏差，相邻RR间隔之间的差的平方和的平均值的平方根，OCD患者RR间期差异≥50ms的数量百分比显着降低，表明副交感神经张力较小。OCD患者的总功率和极低频等频域参数明显较低，表明自主神经音显著下降。OCD患者的非线性参数如垂直于同一性线的点的分散和沿同一性线的点的分散显著降低，表明迷走神经和交感神经张力改变。在自主反应性测试中，强迫症患者在躺到站立测试期间的收缩压下降和在冷加压测试期间的舒张压变化显着改变，表明交感神经反应异常。自主神经参数与强迫症的严重程度之间没有显着相关性。
UNASSIGNED：强迫症的特征是与正常对照组相比，副交感神经张力降低和交感神经反应异常。
