PDF(Pubmed)
Abstract：
Right ventricular (RV) involvement in left ventricular (LV) non-compaction (LVNC) remains unknown. We aimed to describe the RV volumetric, functional, and strain characteristics and clinical features of patients with LVNC phenotype and good LV ejection fraction (EF) using cardiac magnetic resonance to characterize RV trabeculation in LVNC and to study the relationships of RV and LV trabeculation with RV volume and function. This retrospective study included 100 Caucasian patients with LVNC phenotype and good LV-EF and 100 age- and sex-matched healthy controls. Patients were further divided into two subgroups according to RV indexed trabecular mass [RV-TMi; patients with RV hypertrabeculation (RV-HT) vs. patients with normal RV trabeculation (RV-NT)]. We measured the LV and RV volumetric, functional, and TMi values using threshold-based postprocessing software and the RV and LV strain values using feature tracking and collected the patients\' LVNC-related clinical features. Patients had higher RV volumes, lower RV-EF, and worse RV strain values than controls. A total of 22% of patients had RV-TMi values above the reference range; furthermore, RV-HT patients had higher RV and LV volumes, lower RV- and LV-EF, and worse RV strain values than RV-NT patients. We identified a strong positive correlation between RV- and LV-TMi and between RV-TMi and RV volumes and a significant inverse relationship of both RV- and LV-TMi with RV function. The prevalence of LVNC-related clinical features was similar in the RV-HT and RV-NT groups. These results suggest that some patients with LVNC phenotype might have RV non-compaction with subclinical RV dysfunction and without more severe clinical features.
摘要：
右心室（RV）累及左心室（LV）致密化不全（LVNC）仍然未知。我们的目的是描述RV的体积，功能，LVNC表型和左心室射血分数（EF）良好的患者的应变特征和临床特征使用心脏磁共振来表征LVNC中的RV小梁，并研究RV和LV小梁与RV体积和功能的关系。这项回顾性研究包括100名具有LVNC表型和良好LV-EF的白种人患者和100名年龄和性别匹配的健康对照。根据RV指数骨小梁质量[RV-TMi;RV高梁（RV-HT）患者与RV小梁形成正常的患者（RV-NT）]。我们测量了LV和RV的体积，功能，使用基于阈值的后处理软件的TMi值和使用特征跟踪的RV和LV应变值，并收集患者的LVNC相关临床特征。患者的RV容量较高，较低的RV-EF，RV应变值比对照组差。总共22％的患者的RV-TMi值高于参考范围；此外，RV-HT患者的RV和LV体积较高，较低的RV-和LV-EF，RV应变值比RV-NT患者差。我们确定了RV-和LV-TMi之间以及RV-TMi和RV体积之间的强正相关，以及RV-和LV-TMi与RV功能的显着负相关。RV-HT和RV-NT组LVNC相关临床特征的患病率相似。这些结果表明，一些具有LVNC表型的患者可能患有RV非致密化和亚临床RV功能障碍，并且没有更严重的临床特征。
