UNASSIGNED: To raise awareness of HLH among healthcare professionals, particularly intensivists.
UNASSIGNED: We report nine cases of secondary HLH seen at tertiary hospitals in Bloemfontein, South Africa.
UNASSIGNED: All patients presented with fever, hypertriglyceridaemia, hyperferritinaemia, transaminitis and cytopenia. Haemophagocytosis was noted on bone marrow biopsy in 66.7% (n=6/9) of the patients. More than one-third (44.4%; n=4/9) of the cases were triggered by a lymphoma, 44% (n=4/9) were associated with infection and 11% (n=1/9) were associated HIV. Finally, 11.1% (n=1) of the patients were triggered by an underlying autoimmune disease. More than half (55.6%; n=5/9) of the cases had a fatal outcome.
UNASSIGNED: A high index of suspicion may promote the accurate diagnosis of HLH in patients presenting with fever, transaminitis and unexplained cytopenia.
UNASSIGNED: HLH is a rare, life-threatening condition that may be missed in the intensive care setting. This report emphasises the importance of clinical suspicion, early diagnosis and appropriate intervention.
未经批准:为了提高医疗保健专业人员对HLH的认识,尤其是强化主义者。
未经证实:我们报告了布隆方丹三级医院的9例继发性HLH,南非。
未经证实:所有患者均出现发热,高甘油三酯血症,高铁蛋白血症,转氨酶和血细胞减少症。66.7%(n=6/9)的患者在骨髓活检中发现了吞噬作用。超过三分之一(44.4%;n=4/9)的病例是由淋巴瘤引发的,44%(n=4/9)与感染相关,11%(n=1/9)与HIV相关。最后,11.1%(n=1)的患者是由潜在的自身免疫性疾病引发的。超过一半(55.6%;n=5/9)的病例具有致命结局。
未经证实:高怀疑指数可能会促进发热患者HLH的准确诊断,转氨酶和无法解释的血细胞减少症。
未经证实:HLH是一种罕见的,在重症监护环境中可能会错过的危及生命的疾病。这份报告强调了临床怀疑的重要性,早期诊断和适当干预。