PDF(Pubmed)
Abstract：
UNASSIGNED: Patients with cancer and cancer survivors are at increased risk for incident heart failure, but there are conflicting data on the long-term risk for other cardiovascular events and how such risk may vary by cancer site.
UNASSIGNED: The aim of this study was to determine the impact of a new cancer diagnosis on the risk for fatal and nonfatal cardiovascular events.
UNASSIGNED: Using administrative health care databases, a population-based retrospective cohort study was conducted among 4,519,243 adults residing in Alberta, Canada, from April 2007 to December 2018. Participants with new cancer diagnoses during the study period were compared with those without cancer with respect to risk for subsequent cardiovascular events (cardiovascular mortality, myocardial infarction, stroke, heart failure, and pulmonary embolism) using time-to-event survival models after adjusting for sociodemographic data and comorbidities.
UNASSIGNED: A total of 224,016 participants with new cancer diagnoses were identified, as well as 73,360 cardiovascular deaths and 470,481 nonfatal cardiovascular events during a median follow-up period of 11.8 years. After adjustment, participants with cancer had HRs of 1.33 (95% CI: 1.29-1.37) for cardiovascular mortality, 1.01 (95% CI: 0.97-1.05) for myocardial infarction, 1.44 (95% CI: 1.41-1.47) for stroke, 1.62 (95% CI: 1.59-1.65) for heart failure, and 3.43 (95% CI: 3.37-3.50) for pulmonary embolism, compared with participants without cancer. Cardiovascular risk was highest for patients with genitourinary, gastrointestinal, thoracic, nervous system and hematologic malignancies.
UNASSIGNED: A new cancer diagnosis is independently associated with a significantly increased risk for cardiovascular death and nonfatal morbidity regardless of cancer site. These findings highlight the need for a collaborative approach to health care for patients with cancer and cancer survivors.
UNASSIGNED: The aim of this study was to determine the impact of a new cancer diagnosis on the risk for fatal and nonfatal cardiovascular events.
UNASSIGNED: Using administrative health care databases, a population-based retrospective cohort study was conducted among 4,519,243 adults residing in Alberta, Canada, from April 2007 to December 2018. Participants with new cancer diagnoses during the study period were compared with those without cancer with respect to risk for subsequent cardiovascular events (cardiovascular mortality, myocardial infarction, stroke, heart failure, and pulmonary embolism) using time-to-event survival models after adjusting for sociodemographic data and comorbidities.
UNASSIGNED: A total of 224,016 participants with new cancer diagnoses were identified, as well as 73,360 cardiovascular deaths and 470,481 nonfatal cardiovascular events during a median follow-up period of 11.8 years. After adjustment, participants with cancer had HRs of 1.33 (95% CI: 1.29-1.37) for cardiovascular mortality, 1.01 (95% CI: 0.97-1.05) for myocardial infarction, 1.44 (95% CI: 1.41-1.47) for stroke, 1.62 (95% CI: 1.59-1.65) for heart failure, and 3.43 (95% CI: 3.37-3.50) for pulmonary embolism, compared with participants without cancer. Cardiovascular risk was highest for patients with genitourinary, gastrointestinal, thoracic, nervous system and hematologic malignancies.
UNASSIGNED: A new cancer diagnosis is independently associated with a significantly increased risk for cardiovascular death and nonfatal morbidity regardless of cancer site. These findings highlight the need for a collaborative approach to health care for patients with cancer and cancer survivors.
摘要：
未经证实：癌症患者和癌症幸存者发生心力衰竭的风险增加，但是关于其他心血管事件的长期风险以及这些风险如何因癌症部位而异，存在相互矛盾的数据。
UNASSIGNED：本研究的目的是确定新的癌症诊断对致命和非致命心血管事件风险的影响。
未经评估：使用行政医疗保健数据库，一项基于人群的回顾性队列研究在居住在艾伯塔省的4,519,243名成年人中进行，加拿大,从2007年4月到2018年12月。在研究期间有新癌症诊断的参与者与没有癌症的参与者在随后的心血管事件风险方面进行了比较（心血管死亡率，心肌梗塞,中风,心力衰竭,和肺栓塞），在调整社会人口统计学数据和合并症后，使用时间至事件生存模型。
UNASSIGNED：总共224,016名被诊断为新癌症的参与者，以及在11.8年的中位随访期内73,360例心血管死亡和470,481例非致死性心血管事件.调整后,癌症患者心血管死亡率的HR为1.33（95%CI：1.29-1.37），心肌梗死1.01（95%CI：0.97-1.05），中风为1.44（95%CI：1.41-1.47），心力衰竭为1.62（95%CI：1.59-1.65），肺栓塞为3.43（95%CI：3.37-3.50），与没有癌症的参与者相比。泌尿生殖系统患者的心血管风险最高，胃肠,胸廓,神经系统和血液系统恶性肿瘤。
UNASSIGNED：新的癌症诊断与心血管死亡和非致死性发病率的风险显著增加独立相关，无论癌症部位如何。这些发现强调了对癌症患者和癌症幸存者的医疗保健合作方法的必要性。
UNASSIGNED：本研究的目的是确定新的癌症诊断对致命和非致命心血管事件风险的影响。
未经评估：使用行政医疗保健数据库，一项基于人群的回顾性队列研究在居住在艾伯塔省的4,519,243名成年人中进行，加拿大,从2007年4月到2018年12月。在研究期间有新癌症诊断的参与者与没有癌症的参与者在随后的心血管事件风险方面进行了比较（心血管死亡率，心肌梗塞,中风,心力衰竭,和肺栓塞），在调整社会人口统计学数据和合并症后，使用时间至事件生存模型。
UNASSIGNED：总共224,016名被诊断为新癌症的参与者，以及在11.8年的中位随访期内73,360例心血管死亡和470,481例非致死性心血管事件.调整后,癌症患者心血管死亡率的HR为1.33（95%CI：1.29-1.37），心肌梗死1.01（95%CI：0.97-1.05），中风为1.44（95%CI：1.41-1.47），心力衰竭为1.62（95%CI：1.59-1.65），肺栓塞为3.43（95%CI：3.37-3.50），与没有癌症的参与者相比。泌尿生殖系统患者的心血管风险最高，胃肠,胸廓,神经系统和血液系统恶性肿瘤。
UNASSIGNED：新的癌症诊断与心血管死亡和非致死性发病率的风险显著增加独立相关，无论癌症部位如何。这些发现强调了对癌症患者和癌症幸存者的医疗保健合作方法的必要性。
