Abstract：
Three cases of primary Rosai-Dorfman disease of the thymus and lung are presented. The patients are 3 men between the ages of 42 and 47 years who presented with non-specific symptoms including cough, chest pain, and shortness of breath. Clinically, the patients did not have any other pertinent clinical history. Diagnostic imaging revealed in one patient a cystic anterior mediastinal mass, while in two other patients the imaging was that of an intrapulmonary mass, one in the right upper lobe and the other in the left lower lobe. The three patients undergo surgical resection of the mass. In the cases in which the tumor mass was in the lung, both patients had a lobectomy while in the patient with anterior mediastinal mass, surgical resection via thoracotomy was performed. The intrapulmonary tumors were described as soft and yellowish measuring 2.5 and 3.0 cm in greatest diameter, while the mediastinal mass was described as cystic measuring 4.0 cm in diameter. Histologically, all tumors show similar features in terms of a proliferation of large histiocytes admixed with an inflammatory component composed predominantly of plasma cells. Immunohistochemical stains show positive staining for CD68 and S-100 protein, while negative for keratin, CD1a, and langerin. The cases herein presented highlight the ubiquitous distribution of Rosai-Dorfman disease and the importance of keeping this entity in the differential diagnosis of histiocytic proliferation in the thymus or lung.
摘要：
介绍了三例原发性胸腺和肺部Rosai-Dorfman病。患者是3名年龄在42至47岁之间的男性，他们表现出包括咳嗽在内的非特异性症状，胸痛,呼吸急促.临床上,这些患者没有任何其他相关的临床病史.诊断成像显示一名患者囊性前纵隔肿块，而在另外两名患者中，成像是肺内肿块的成像，一个在右上叶，另一个在左下叶。三名患者接受了肿块的手术切除。在肿瘤块在肺部的情况下，两名患者在患有前纵隔肿块的患者中进行了肺叶切除术，通过开胸手术切除。肺内肿瘤被描述为柔软和黄色，最大直径为2.5和3.0厘米，纵隔肿块被描述为直径4.0厘米的囊性肿块。组织学上,所有肿瘤在大组织细胞增殖与主要由浆细胞组成的炎症成分混合方面表现出相似的特征.免疫组织化学染色显示CD68和S-100蛋白阳性染色，虽然角蛋白呈阴性，CD1a,还有Langerin.本文介绍的病例突出了Rosai-Dorfman病的普遍存在分布以及在胸腺或肺组织细胞增殖的鉴别诊断中保持该实体的重要性。
