Abstract：
This revision of the original poultry guidelines has been prepared to assist in the planning, conduct and interpretation of studies designed to assess the anthelmintic efficacy of drugs (newly discovered or currently used) against helminth parasites of chickens and turkeys. The original set of poultry guidelines was published in 2003. The current version provides an update on procedures to study and quantify the most important helminth parasites of chickens and turkeys, and to integrate these poultry guidelines with a new series of general, reflective and host-specific guidelines relative to assessing anthelmintic efficacy in production and companion animals. General considerations required for the conduct of studies designed to evaluate anthelmintics regardless of animal host such as the selection of study animals, animal housing, feeding, study design, record keeping and statistical analysis are for the most part provided in the newly published general guidelines. Taken together, the general and poultry guidelines should help investigators and others design and conduct studies and evaluate data concerned with determining the efficacy and safety of anthelmintics in chickens and turkeys. Additionally, this revision draws attention to several timely considerations inherent to anthelmintic evaluations such as the need to properly collect helminth specimens for subsequent determinations (e.g. species and stage verification, helminth genotyping). The investigations addressed herein, will most likely provide the very first public record of a new product\'s abilities to effectively reduce targeted, helminth infections in animals, and particular attention should be focused on study excellence and accuracy. Due to changes in consumer preferences, and new regulatory requirements, poultry husbandry, especially regarding laying hens, has changed immensely in many countries since the publication of the first poultry guidelines. These changes have generally allowed for a much greater exposure of birds to the source of helminth challenge (litter and fields as opposed to cages). Parasitic helminthiosis of poultry has therefore greatly increased in incidence and magnitude; changes that accentuate the need for more effective anthelmintic intervention and an update on the means of determining anthelmintic efficacy.
摘要：
这次修订原有家禽指引是为协助规划而编制的,进行和解释旨在评估药物（新发现或目前使用的）对鸡和火鸡的蠕虫寄生虫的驱虫功效的研究。最初的家禽指南于2003年发布。当前版本提供了有关研究和量化鸡和火鸡最重要的蠕虫寄生虫的程序的更新，并将这些家禽指南与一系列新的通用指南相结合，与评估生产和伴侣动物中驱虫功效有关的反射和宿主特异性指南。进行旨在评估驱虫药而不考虑动物宿主的研究所需的一般考虑因素，例如研究动物的选择，动物住房,喂养,研究设计，记录保存和统计分析大部分在新出版的一般准则中提供。一起来看,一般和家禽指南应帮助研究人员和其他人设计和进行研究，并评估与确定驱虫药在鸡和火鸡中的功效和安全性有关的数据。此外,本修订提请注意驱虫药评估固有的几个及时考虑因素，例如需要适当收集蠕虫标本以进行后续确定(例如物种和阶段验证，蠕虫基因分型）。本文涉及的调查，将最有可能提供一个新产品的能力的第一个公开记录，以有效地降低针对性，动物的蠕虫感染，特别要注意的是学习的精益求精和准确性。由于消费者偏好的变化，和新的监管要求，家禽饲养,尤其是关于蛋鸡，自第一个家禽指南发布以来，许多国家都发生了巨大变化。这些变化通常使鸟类更多地暴露于蠕虫挑战的来源（垃圾和田地，而不是笼子）。因此，家禽的寄生虫病的发生率和程度大大增加；这些变化强调了对更有效的驱虫干预的需求以及对确定驱虫疗效的方法的更新。
