Abstract：
OBJECTIVE: To investigate the diagnostic value of International Ovarian Tumor Analysis (IOTA) simple rules combined with contrast-enhanced ultrasound (CEUS) scoring system in the differential diagnosis of ovarian tumors, and the correlations of the scoring system with microvessel density (MVD) and vascular endothelial growth factor (VEGF).
METHODS: One hundred eighty-nine patients with ovarian tumors were examined by routine ultrasound and CEUS. The enhanced characteristics of CEUS were observed, and the masses were classified by IOTA simple rules. To compare the diagnostic value of IOTA simple rules combined with CEUS scoring system and IOTA simple rules in the diagnosis of ovarian tumors. Immunohistochemistry was used to detect the expression of MVD and VEGF in postoperative tissue samples. The correlations between the new scoring system with MVD and VEGF were analyzed.
RESULTS: The sensitivity (93.98%), specificity (94.34%), positive predictive value (92.86%), negative predictive value (95.24%), and accuracy (94.18%) of IOTA simple rules combined with CEUS scoring system in the diagnosis of ovarian tumors were higher than those of IOTA simple rules alone (all P < .05). The score system was significantly positively correlated with MVD and VEGF, and the r values were 0.77 and 0.63, respectively (P < .001).
CONCLUSIONS: IOTA simple rules combined with CEUS scoring system was helpful to improve the accuracy of ultrasound diagnosis of ovarian tumors, which was significantly correlated with MVD and VEGF. It could provide important reference information for treatment scheme formulation and prognosis evaluation.
METHODS: One hundred eighty-nine patients with ovarian tumors were examined by routine ultrasound and CEUS. The enhanced characteristics of CEUS were observed, and the masses were classified by IOTA simple rules. To compare the diagnostic value of IOTA simple rules combined with CEUS scoring system and IOTA simple rules in the diagnosis of ovarian tumors. Immunohistochemistry was used to detect the expression of MVD and VEGF in postoperative tissue samples. The correlations between the new scoring system with MVD and VEGF were analyzed.
RESULTS: The sensitivity (93.98%), specificity (94.34%), positive predictive value (92.86%), negative predictive value (95.24%), and accuracy (94.18%) of IOTA simple rules combined with CEUS scoring system in the diagnosis of ovarian tumors were higher than those of IOTA simple rules alone (all P < .05). The score system was significantly positively correlated with MVD and VEGF, and the r values were 0.77 and 0.63, respectively (P < .001).
CONCLUSIONS: IOTA simple rules combined with CEUS scoring system was helpful to improve the accuracy of ultrasound diagnosis of ovarian tumors, which was significantly correlated with MVD and VEGF. It could provide important reference information for treatment scheme formulation and prognosis evaluation.
摘要：
目的：探讨国际卵巢肿瘤分析(IOTA)简易规则结合超声造影(CEUS)评分系统对卵巢肿瘤的鉴别诊断价值。以及评分系统与微血管密度（MVD）和血管内皮生长因子（VEGF）的相关性。
方法：对99例卵巢肿瘤患者进行常规超声和CEUS检查。观察到CEUS的增强特性，群众按IOTA简单规则分类。比较IOTA简单规则联合CEUS评分系统与IOTA简单规则在卵巢肿瘤诊断中的诊断价值。免疫组化法检测术后组织标本中MVD和VEGF的表达。分析新评分系统与MVD和VEGF的相关性。
结果：灵敏度（93.98%），特异性（94.34%），阳性预测值（92.86%），阴性预测值（95.24%），IOTA简单规则联合CEUS评分系统诊断卵巢肿瘤的准确率(94.18%)高于单用IOTA简单规则(均P<0.05)。评分系统与MVD、VEGF呈显著正相关,r值分别为0.77和0.63(P<.001)。
结论：IOTA简易规则结合CEUS评分系统有助于提高超声诊断卵巢肿瘤的准确性。与MVD和VEGF显著相关。可为治疗方案制定和预后评估提供重要的参考信息。
方法：对99例卵巢肿瘤患者进行常规超声和CEUS检查。观察到CEUS的增强特性，群众按IOTA简单规则分类。比较IOTA简单规则联合CEUS评分系统与IOTA简单规则在卵巢肿瘤诊断中的诊断价值。免疫组化法检测术后组织标本中MVD和VEGF的表达。分析新评分系统与MVD和VEGF的相关性。
结果：灵敏度（93.98%），特异性（94.34%），阳性预测值（92.86%），阴性预测值（95.24%），IOTA简单规则联合CEUS评分系统诊断卵巢肿瘤的准确率(94.18%)高于单用IOTA简单规则(均P<0.05)。评分系统与MVD、VEGF呈显著正相关,r值分别为0.77和0.63(P<.001)。
结论：IOTA简易规则结合CEUS评分系统有助于提高超声诊断卵巢肿瘤的准确性。与MVD和VEGF显著相关。可为治疗方案制定和预后评估提供重要的参考信息。
