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Abstract：
UNASSIGNED: Drug interactions are important causes of adverse events. Assessments of pharmacological interactions outside healthcare services settings are scarce.
UNASSIGNED: To assess the frequency and factors associated with these potential interactions in adults living in Manaus, Amazonas, Brazil.
UNASSIGNED: We conducted a case-control study in 2019 with residents who had taken two or more medicines two weeks before the interview. The cases involved people with potential drug interaction, according to Micromedex™, and adults without drug interactions formed the control group. The factors associated with interaction were identified by multivariate logistic regression.
UNASSIGNED: 752 adults out of 2321 interviewed were using two or more medicines and were included. The prevalence of potential drug interactions was 30.2% (95% CI: 26.9; 33.5%). We identified 457 drug interactions, more frequently one interaction per person (49.7%), of major severity (61.9%), and with fair documentation (61.7%); three individuals were using contraindicated associations. Individuals aged 45-59 years (OR 1.88, 95% CI 1.03-3.42), using 3 or more drugs simultaneously (p-value<0.001), had higher chance of drug interactions.
UNASSIGNED: Drug interaction was common in among adults living in Manaus, mostly of major severity. The odds of interaction increased with age and number of concomitantly medicines.
UNASSIGNED: To assess the frequency and factors associated with these potential interactions in adults living in Manaus, Amazonas, Brazil.
UNASSIGNED: We conducted a case-control study in 2019 with residents who had taken two or more medicines two weeks before the interview. The cases involved people with potential drug interaction, according to Micromedex™, and adults without drug interactions formed the control group. The factors associated with interaction were identified by multivariate logistic regression.
UNASSIGNED: 752 adults out of 2321 interviewed were using two or more medicines and were included. The prevalence of potential drug interactions was 30.2% (95% CI: 26.9; 33.5%). We identified 457 drug interactions, more frequently one interaction per person (49.7%), of major severity (61.9%), and with fair documentation (61.7%); three individuals were using contraindicated associations. Individuals aged 45-59 years (OR 1.88, 95% CI 1.03-3.42), using 3 or more drugs simultaneously (p-value<0.001), had higher chance of drug interactions.
UNASSIGNED: Drug interaction was common in among adults living in Manaus, mostly of major severity. The odds of interaction increased with age and number of concomitantly medicines.
摘要：
未经批准：药物相互作用是不良事件的重要原因。对医疗服务机构以外的药物相互作用的评估很少。
UNASSIGNED：为了评估生活在玛瑙斯的成年人中与这些潜在相互作用相关的频率和因素，亚马逊,巴西。
UNASSIGNED：我们在2019年对采访前两周服用两种或两种以上药物的居民进行了病例对照研究。这些病例涉及有潜在药物相互作用的人，根据Micromedex™，没有药物相互作用的成年人组成对照组。通过多变量逻辑回归确定与相互作用相关的因素。
UNASSIGNED：在2321名访谈中，有752名成年人使用了两种或两种以上的药物。潜在药物相互作用的患病率为30.2%（95%CI：26.9；33.5%）。我们确定了457种药物相互作用，每人一次互动的频率更高(49.7%)，严重程度（61.9%），并有公平的文件(61.7%)；三人使用禁忌协会。45-59岁的个人（OR1.88，95%CI1.03-3.42），同时使用3种或更多种药物（p值<0.001），有更高的机会的药物相互作用。
未经批准：药物相互作用在生活在玛瑙斯的成年人中很常见，主要是严重的。相互作用的几率随着年龄和伴随药物的数量而增加。
UNASSIGNED：为了评估生活在玛瑙斯的成年人中与这些潜在相互作用相关的频率和因素，亚马逊,巴西。
UNASSIGNED：我们在2019年对采访前两周服用两种或两种以上药物的居民进行了病例对照研究。这些病例涉及有潜在药物相互作用的人，根据Micromedex™，没有药物相互作用的成年人组成对照组。通过多变量逻辑回归确定与相互作用相关的因素。
UNASSIGNED：在2321名访谈中，有752名成年人使用了两种或两种以上的药物。潜在药物相互作用的患病率为30.2%（95%CI：26.9；33.5%）。我们确定了457种药物相互作用，每人一次互动的频率更高(49.7%)，严重程度（61.9%），并有公平的文件(61.7%)；三人使用禁忌协会。45-59岁的个人（OR1.88，95%CI1.03-3.42），同时使用3种或更多种药物（p值<0.001），有更高的机会的药物相互作用。
未经批准：药物相互作用在生活在玛瑙斯的成年人中很常见，主要是严重的。相互作用的几率随着年龄和伴随药物的数量而增加。
