Abstract：
BACKGROUND: Parkinson disease is a neurodegenerative disorder characterized by motor and non-motor symptoms. Symptomatic treatment is based on dopaminergic medications. In case of self-medication practices, there may be drug-drug interactions between over-the-counter medication and dopaminergic medications. Thus, the aim of our work was to develop a practical guide summarizing drug-drug interactions and assess it by patients and community pharmacy professionals.
METHODS: We performed a systematic analysis of drug-drug interactions between OTC medications available in France and antiparkinsonians (ATC Class N04) using Theriaque® and Drugs® databases, and summarized the results in a practical guide. We assessed patients\' satisfaction by a questionnaire administered to hospitalized patients in a French expert center for Parkinson\'s disease. We estimated the impact of the guide on community pharmacy professionals through a survey online, by satisfaction, knowledge acquisition and estimated awareness in professional context.
RESULTS: We identified 16 OTC medication, related to seven symptoms, interacting with antiparkinsonians. We obtained 67 responses from patients, expressing high satisfaction. We obtained 101 responses from professionals, reporting high satisfaction, knowledge acquisition and increased awareness in professional context.
CONCLUSIONS: Our results highlight the relevance of the guide and suggest that we may increase its dissemination to patients and community pharmacies.
METHODS: We performed a systematic analysis of drug-drug interactions between OTC medications available in France and antiparkinsonians (ATC Class N04) using Theriaque® and Drugs® databases, and summarized the results in a practical guide. We assessed patients\' satisfaction by a questionnaire administered to hospitalized patients in a French expert center for Parkinson\'s disease. We estimated the impact of the guide on community pharmacy professionals through a survey online, by satisfaction, knowledge acquisition and estimated awareness in professional context.
RESULTS: We identified 16 OTC medication, related to seven symptoms, interacting with antiparkinsonians. We obtained 67 responses from patients, expressing high satisfaction. We obtained 101 responses from professionals, reporting high satisfaction, knowledge acquisition and increased awareness in professional context.
CONCLUSIONS: Our results highlight the relevance of the guide and suggest that we may increase its dissemination to patients and community pharmacies.
摘要：
背景：帕金森病是一种以运动和非运动症状为特征的神经退行性疾病。对症治疗基于多巴胺能药物。在自我药疗的情况下，非处方药和多巴胺能药物之间可能存在药物相互作用.因此，我们工作的目的是制定一个总结药物-药物相互作用的实用指南,并由患者和社区药学专业人员进行评估.
方法：我们使用Theriaque®和Drugs®数据库，对法国现有的OTC药物与抗帕金森病（ATCClassN04）之间的药物-药物相互作用进行了系统分析。并将结果总结为实用指南。我们通过在法国帕金森氏病专家中心对住院患者进行问卷调查来评估患者的满意度。我们透过一项网上调查,估计指南对社区药房专业人士的影响,满意,专业背景下的知识获取和估计意识。
结果：我们确定了16种非处方药，与七个症状有关，与反帕金森病人互动。我们从患者那里获得了67个应答，表达很高的满意度。我们从专业人士那里获得了101个回复，报告满意度高，在专业背景下获得知识和提高意识。
结论：我们的研究结果突出了该指南的相关性，并建议我们可以增加其在患者和社区药房的传播。
方法：我们使用Theriaque®和Drugs®数据库，对法国现有的OTC药物与抗帕金森病（ATCClassN04）之间的药物-药物相互作用进行了系统分析。并将结果总结为实用指南。我们通过在法国帕金森氏病专家中心对住院患者进行问卷调查来评估患者的满意度。我们透过一项网上调查,估计指南对社区药房专业人士的影响,满意,专业背景下的知识获取和估计意识。
结果：我们确定了16种非处方药，与七个症状有关，与反帕金森病人互动。我们从患者那里获得了67个应答，表达很高的满意度。我们从专业人士那里获得了101个回复，报告满意度高，在专业背景下获得知识和提高意识。
结论：我们的研究结果突出了该指南的相关性，并建议我们可以增加其在患者和社区药房的传播。
