PDF(Pubmed)
Abstract：
Schwannomatosis is a rare subset of neurofibromatosis. It is a disease process with a predisposition to schwannomas in the absence of bilateral vestibular schwannomas, which differentiates it from neurofibromatosis 2 (NF2). It is occasionally associated with certain tumors such as malignant peripheral nerve sheath tumors or rhabdoid tumors. Currently, there is limited literature to suggest an association between schwannomatosis and glioblastoma (GB). We present a case of a 55-year-old female with a history significant for schwannomatosis who presented after a witnessed first-time seizure with left facial weakness and slurred speech. She was found to have a 3 cm right-sided ring-enhancing lesion that was excised and found to be a grade IV Isocitrate dehydrogenase (IDH) wildtype GB.
摘要：
神经鞘瘤病是神经纤维瘤病的一个罕见子集。在没有双侧前庭神经鞘瘤的情况下，这是一种易于发生神经鞘瘤的疾病过程。将其与神经纤维瘤病2（NF2）区分开。它偶尔与某些肿瘤有关，例如恶性周围神经鞘瘤或横纹肌样瘤。目前,有限的文献表明神经鞘瘤病和胶质母细胞瘤(GB)之间存在关联.我们介绍了一例55岁的女性，其病史对神经鞘瘤病具有重要意义，该患者在目睹首次癫痫发作并伴有左侧面部无力和言语不清后出现。发现她有一个3厘米的右侧增强环病变，该病变被切除，发现是IV级异柠檬酸脱氢酶（IDH）野生型GB。
