Abstract：
BACKGROUND: Imatinib Mesylate (IM), a tyrosine kinase inhibitor, has been reported to cause several adverse reactions, most of them with cutaneous involvement. Non- Lichenoid IM associated skin reactions have been sufficiently- recorded. To our knowledge, Lichenoid Drug Eruption (LDE) is recorded in a minority of registries.
METHODS: To describe an LDE induced case by IM treatment.
RESULTS: Histological Confirmation and promptly dermatological consultation relieved successfully the cutaneous adverse event.
CONCLUSIONS: Ongoing expansion of IM usage in a wide spectrum of new indications is more likely to make physicians experience such LDE cutaneous side effects more often. Hence, they should be highly suspicious to early detect these distinct histologic entities, handle these undesired complications and guarantee satisfactory immediate outcomes, avoiding frivolous IM dosage modifications.
METHODS: To describe an LDE induced case by IM treatment.
RESULTS: Histological Confirmation and promptly dermatological consultation relieved successfully the cutaneous adverse event.
CONCLUSIONS: Ongoing expansion of IM usage in a wide spectrum of new indications is more likely to make physicians experience such LDE cutaneous side effects more often. Hence, they should be highly suspicious to early detect these distinct histologic entities, handle these undesired complications and guarantee satisfactory immediate outcomes, avoiding frivolous IM dosage modifications.
摘要：
背景：甲磺酸伊马替尼（IM），酪氨酸激酶抑制剂，据报道会导致一些不良反应，大部分都有皮肤受累.非苔藓样IM相关的皮肤反应已被充分记录。据我们所知,苔藓样药物爆发（LDE）记录在少数注册表中。
方法：描述通过IM治疗引起LDE的病例。
结果：组织学确认和及时皮肤科会诊成功缓解了皮肤不良事件。
结论：在广泛的新适应症中持续扩大IM的使用更有可能使医生更频繁地经历这种LDE皮肤副作用。因此，他们应该高度怀疑早期发现这些不同的组织学实体，处理这些不希望的并发症，并保证令人满意的即时结果，避免琐碎的IM剂量修改。
方法：描述通过IM治疗引起LDE的病例。
结果：组织学确认和及时皮肤科会诊成功缓解了皮肤不良事件。
结论：在广泛的新适应症中持续扩大IM的使用更有可能使医生更频繁地经历这种LDE皮肤副作用。因此，他们应该高度怀疑早期发现这些不同的组织学实体，处理这些不希望的并发症，并保证令人满意的即时结果，避免琐碎的IM剂量修改。
