UNASSIGNED: A narrative review was written to further study preclinical and clinical evidence for the role of IL-36 in psoriasis, atopic dermatitis (AD), hidradenitis suppurativa (HS), acne, autoimmune blistering diseases, and neutrophilic dermatoses.
UNASSIGNED: IL-36 has important downstream effects such as inducing expression of inflammatory cytokines, antimicrobial peptides, and growth factors. Increased expression of IL-36 cytokines has been observed in the lesional skin of patients with psoriasis. Studies of other inflammatory skin diseases have also noted similar findings, albeit to a lesser extent. IL-36 inhibition has been shown to be effective in GPP and is currently being studied for other inflammatory skin diseases.
UNASSIGNED: The IL-36 pathway contributes to pathogenesis of many inflammatory skin diseases and is a promising therapeutic target.
UASSIGNED:撰写了叙述性综述,以进一步研究IL-36在银屑病中的作用的临床前和临床证据,特应性皮炎(AD),化脓性汗腺炎(HS),痤疮,自身免疫性起泡疾病,和嗜中性皮肤病。
未经证实:IL-36具有重要的下游作用,如诱导炎症细胞因子的表达,抗菌肽,和增长因素。已在牛皮癣患者的皮损中观察到IL-36细胞因子的表达增加。其他炎症性皮肤病的研究也注意到类似的发现,虽然程度较小。IL-36抑制已被证明是有效的,目前正在研究其他炎症性皮肤病。
未经证实:IL-36途径与许多炎症性皮肤病的发病机制有关,是一个有前途的治疗靶点。