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Abstract：
UNASSIGNED: Few studies have reported the influence of the histological classification of type-2 papillary renal cell carcinoma (PRCC), which may differ from that of clear cell renal carcinoma (ccRCC), on the prognosis of renal cell carcinoma with tumor thrombus. We investigated the clinicopathological features and prognosis of type-2 PRCC associated with venous tumor thrombi (PRCC-TT).
UNASSIGNED: We retrospectively analyzed 163 patients with renal cell carcinoma with venous tumor thrombus (RCC-TT) admitted to Peking University Third Hospital between June 2016 and June 2020. Twenty-five patients had type-2 PRCC-TT and 138 had ccRCC combined with tumor thrombus; there were 125 males and 38 females. All the included patients underwent radical nephrectomy and thrombectomy under either complete laparoscopic surgery or open surgery. Univariate and multivariate Cox regression analysis were performed to evaluate the prognostic significance of each variable on cancer-specific survival (CSS). Cancer-specific survival was calculated from the date of surgery to death or the last follow-up using the Kaplan-Meier method.
UNASSIGNED: The blood vessels of type-2 PRCC-TT presented on CT images were not as abundant as those of ccRCC-TT. Slight enhancement was observed in the corticomedullary phase. While wash-out symptoms were observed, contrast agent extinction was not obvious in the nephrographic and excretory phases. We compared the macroscopic and microscopic appearances of the 2 cohorts. Compared to the ccRCC-TT cohort, lymph node invasion was more prevalent in the PRCC-TT cohort (88.0% vs. 60.9%, P = .009). Multivariate analysis revealed that sarcomatoid differentiation, distant metastasis, and pathological type were the independent predictors of poor CSS. The Kaplan-Meier analysis showed that the CSS of type-2 PRCC-TT and ccRCC-TT were 23.5 and 38.4 months, respectively, with statistical significance (P = .002).
UNASSIGNED: Type-2 PRCC-TT varies with common ccRCC-TT in imaging manifestation and pathological characteristics. The prognosis of type-2 PRCC-TT patients was worse than that of ccRCC-TT patients.
UNASSIGNED: We retrospectively analyzed 163 patients with renal cell carcinoma with venous tumor thrombus (RCC-TT) admitted to Peking University Third Hospital between June 2016 and June 2020. Twenty-five patients had type-2 PRCC-TT and 138 had ccRCC combined with tumor thrombus; there were 125 males and 38 females. All the included patients underwent radical nephrectomy and thrombectomy under either complete laparoscopic surgery or open surgery. Univariate and multivariate Cox regression analysis were performed to evaluate the prognostic significance of each variable on cancer-specific survival (CSS). Cancer-specific survival was calculated from the date of surgery to death or the last follow-up using the Kaplan-Meier method.
UNASSIGNED: The blood vessels of type-2 PRCC-TT presented on CT images were not as abundant as those of ccRCC-TT. Slight enhancement was observed in the corticomedullary phase. While wash-out symptoms were observed, contrast agent extinction was not obvious in the nephrographic and excretory phases. We compared the macroscopic and microscopic appearances of the 2 cohorts. Compared to the ccRCC-TT cohort, lymph node invasion was more prevalent in the PRCC-TT cohort (88.0% vs. 60.9%, P = .009). Multivariate analysis revealed that sarcomatoid differentiation, distant metastasis, and pathological type were the independent predictors of poor CSS. The Kaplan-Meier analysis showed that the CSS of type-2 PRCC-TT and ccRCC-TT were 23.5 and 38.4 months, respectively, with statistical significance (P = .002).
UNASSIGNED: Type-2 PRCC-TT varies with common ccRCC-TT in imaging manifestation and pathological characteristics. The prognosis of type-2 PRCC-TT patients was worse than that of ccRCC-TT patients.
摘要：
未经证实：很少有研究报道2型乳头状肾细胞癌（PRCC）的组织学分类的影响，可能与透明细胞肾癌（ccRCC）不同，肾细胞癌合并癌栓的预后。我们调查了与静脉肿瘤血栓相关的2型PRCC（PRCC-TT）的临床病理特征和预后。
UNASSIGNED：我们回顾性分析北京大学第三医院2016年6月至2020年6月收治的163例肾细胞癌伴静脉癌栓（RCC-TT）患者。25例患者患有2型PRCC-TT，138例患有ccRCC合并肿瘤血栓；男性125例，女性38例。所有纳入的患者均在完全腹腔镜手术或开放手术下接受了根治性肾切除术和血栓切除术。进行单变量和多变量Cox回归分析以评估每个变量对癌症特异性生存（CSS）的预后意义。使用Kaplan-Meier方法计算从手术日期到死亡或最后一次随访的癌症特异性存活率。
未经证实：CT图像上显示的2型PRCC-TT血管不如ccRCC-TT血管丰富。在皮质髓质阶段观察到轻微增强。虽然观察到冲洗症状，在肾图和排泄阶段，造影剂消失不明显。我们比较了两个队列的宏观和微观外观。与ccRCC-TT队列相比，淋巴结浸润在PRCC-TT队列中更为普遍(88.0%vs.60.9%,P=.009）。多因素分析显示肉瘤样分化，远处转移,病理类型是CSS差的独立预测因子。Kaplan-Meier分析表明，2型PRCC-TT和ccRCC-TT的CSS分别为23.5和38.4个月，分别,具有统计学意义（P=0.002）。
未经证实：2型PRCC-TT在影像学表现和病理特征上与常见ccRCC-TT不同。2型PRCC-TT患者的预后比ccRCC-TT患者差。
UNASSIGNED：我们回顾性分析北京大学第三医院2016年6月至2020年6月收治的163例肾细胞癌伴静脉癌栓（RCC-TT）患者。25例患者患有2型PRCC-TT，138例患有ccRCC合并肿瘤血栓；男性125例，女性38例。所有纳入的患者均在完全腹腔镜手术或开放手术下接受了根治性肾切除术和血栓切除术。进行单变量和多变量Cox回归分析以评估每个变量对癌症特异性生存（CSS）的预后意义。使用Kaplan-Meier方法计算从手术日期到死亡或最后一次随访的癌症特异性存活率。
未经证实：CT图像上显示的2型PRCC-TT血管不如ccRCC-TT血管丰富。在皮质髓质阶段观察到轻微增强。虽然观察到冲洗症状，在肾图和排泄阶段，造影剂消失不明显。我们比较了两个队列的宏观和微观外观。与ccRCC-TT队列相比，淋巴结浸润在PRCC-TT队列中更为普遍(88.0%vs.60.9%,P=.009）。多因素分析显示肉瘤样分化，远处转移,病理类型是CSS差的独立预测因子。Kaplan-Meier分析表明，2型PRCC-TT和ccRCC-TT的CSS分别为23.5和38.4个月，分别,具有统计学意义（P=0.002）。
未经证实：2型PRCC-TT在影像学表现和病理特征上与常见ccRCC-TT不同。2型PRCC-TT患者的预后比ccRCC-TT患者差。
