PDF(Pubmed)
Abstract：
Complete nutrition drinks with a low glycemic index (GI) provide nutritional support and prevent hyperglycaemia. The present study identified GI and factors predicting individual glucose response to a new complete nutrition drink. A randomised cross-over controlled trial was conducted in eighteen healthy volunteers (FPG < 100 mg/dl). Complete nutrition drinks containing retrograded starch, glucose solution and white bread were assigned in a random sequence with 14-day wash-out intervals. Plasma glucose and insulin levels were measured from baseline to 180 min after consuming each food. Results show the adjusted GIs of the drink was 48.2 ± 10.4 and 46.7 ± 12.7 with glucose and white bread as the reference, respectively. While the drink has low GI (<55), the individual glucose responses varied (GI: 7-149). Comparing characters in individual GI < 55 (n = 12) and GI ≥ 55 (n = 6) groups revealed significantly higher baseline insulin in the low GI group (14.86 ± 16.51 μIU/ml v. 4.9 ± 3.4 μIU/ml, P < 0·05). The correlation matrix confirms only two predictive factors for having individual GI <55 were baseline insulin (r = 0·5, P = 0·03) and HOMA-IR (r = 0·55, P = 0·02). ROC curve reveals fasting insulin above 1.6 μIU/ml and HOMA-IR above 1.05 as the cut-off values. The findings suggest that the complete nutrition drink has a low GI, but there was wide variability in individual responses partly explained by fasting insulin levels and HOMA-IR. Screening for fasting insulin and HOMA-IR may be encouraged to maximise the functional benefit of the drink.
摘要：
具有低血糖指数（GI）的完全营养饮料提供营养支持并预防高血糖。本研究确定了GI和预测个体对新的完全营养饮料的葡萄糖反应的因素。在18名健康志愿者(FPG<100mg/dl)中进行随机交叉对照试验。含有逆行淀粉的全营养饮料，葡萄糖溶液和白面包以随机顺序分配，间隔14天。从基线到食用每种食物后180分钟测量血浆葡萄糖和胰岛素水平。结果表明，以葡萄糖和白面包为参考，调整后的饮料GI分别为48.2±10.4和46.7±12.7，分别。虽然饮料具有低GI（<55），个体葡萄糖反应不同(GI:7-149)。比较个别GI<55（n=12）和GI≥55（n=6）组的特征显示，低GI组的基线胰岛素明显更高（14.86±16.51μIU/ml与4.9±3.4μIU/ml，P<0·05)。相关矩阵仅证实个体GI<55的两个预测因素是基线胰岛素（r=0·5，P=0·03）和HOMA-IR（r=0·55，P=0·02）。ROC曲线显示空腹胰岛素高于1.6μIU/ml，HOMA-IR高于1.05作为临界值。研究结果表明，完全营养饮料具有低GI，但个体反应存在很大差异,部分原因是空腹胰岛素水平和HOMA-IR.可以鼓励筛选空腹胰岛素和HOMA-IR以最大化饮料的功能益处。
