Abstract:
Poor diet quality influences cardiometabolic risk. Although potatoes are suggested to adversely affect cardiometabolic health, controlled trials that can establish causality are limited. Consistent with potatoes being rich in micronutrients and resistant starch, we hypothesized that their inclusion in a Dietary Guidelines for Americans (DGA)-based dietary pattern would improve cardiometabolic and gut health in metabolic syndrome (MetS) persons. In a randomized cross-over trial, MetS persons (n = 27; 32.5 ± 1.3 year) consumed a DGA-based diet for 2 weeks containing potatoes (DGA + POTATO; 17.5 g/day resistant starch) or bagels (DGA + BAGEL; 0 g/day resistant starch) prior to completing oral glucose and gut permeability tests. Blood pressure, fasting glucose and insulin, and insulin resistance decreased (p < 0.05) from baseline regardless of treatment without any change in body mass. Oral glucose-induced changes in brachial artery flow-mediated dilation, nitric oxide homeostasis, and lipid peroxidation did not differ between treatment arms. Serum endotoxin AUC0−120 min and urinary lactulose/mannitol, but not urinary sucralose/erythritol, were lower in DGA + POTATO. Fecal microbiome showed limited between-treatment differences, but the proportion of acetate was higher in DGA + POTATO. Thus, short-term consumption of a DGA-based diet decreases cardiometabolic risk, and the incorporation of resistant starch-containing potatoes into a healthy diet reduces small intestinal permeability and postprandial endotoxemia.
摘要:
不良饮食质量影响心脏代谢风险。虽然土豆被认为会对心脏代谢健康产生不利影响,能够确定因果关系的对照试验是有限的。与土豆富含微量营养素和抗性淀粉一致,我们假设将它们纳入以美国人饮食指南(DGA)为基础的饮食模式将改善代谢综合征(MetS)患者的心脏代谢和肠道健康.在一项随机交叉试验中,MetS人(n=27;32.5±1.3年)食用以DGA为基础的饮食2周,其中含有土豆(DGAPOTATO;17.5g/天抗性淀粉)或百吉饼(DGABAGEL;0g/天抗性淀粉)。完成口服葡萄糖和肠道通透性测试。血压,空腹血糖和胰岛素,和胰岛素抵抗从基线下降(p<0.05),无论治疗,体重没有任何变化。口服葡萄糖引起的肱动脉血流介导的扩张变化,一氧化氮稳态,和脂质过氧化在治疗组之间没有差异。血清内毒素AUC0−120分钟和尿乳果糖/甘露醇,但不是尿三氯蔗糖/赤藓糖醇,在DGA+马铃薯中较低。粪便微生物组显示治疗之间的差异有限,但DGA+马铃薯中乙酸盐的比例较高。因此,短期食用基于DGA的饮食可降低心脏代谢风险,在健康饮食中掺入含有抗性淀粉的马铃薯可减少小肠通透性和餐后内毒素血症。