Abstract：
Background: Periodontal pathogens are related to the incidence of systemic diseases. This study aimed to examine whether periodontal pathogen burden is associated with the risk of fever onset in older adults. Methods: Older adults in nursing homes, aged ≥65 years, were enrolled. The study was set in Kitakyushu, Japan. The body temperatures of participants were ≥37.2 °C and were recorded for eight months. As periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia were qualified by a real-time polymerase chain reaction at the baseline. For statistical analysis, the number of bacterial counts was logarithmically conversed to 10 as a base. Results: Data from 56 participants with a median age of 88 (62−98) years were available for analysis. The logarithmic-conversed bacterial counts of T. forsythia, but not P. gingivalis or T. denticola, were associated with the onset of fever in older residents. The Kaplan−Meier method revealed that the group with <104 of T. forsythia had significantly less cumulative fever incidence than the group with ≥104 of T. forsythia. The group with ≥104 of T. forsythia was associated with an increased risk of fever onset (hazard ratio, 3.7; 98% confidence interval, 1.3−10.2; p = 0.012), which was adjusted for possible confounders. Conclusions: Bacterial burden of T. forsythia in the oral cavity was associated with the risk of the onset of fever in older nursing homes residents.
摘要：
背景：牙周病原体与全身疾病的发生有关。这项研究旨在检查牙周病原体负担是否与老年人发烧的风险有关。方法：养老院的老年人，年龄≥65岁，已注册。这项研究是在北九州进行的，日本。参与者的体温≥37.2°C，并记录了八个月。作为牙周病原体，牙龈卟啉单胞菌,Denticola密螺旋体,和连翘坦纳菌在基线时通过实时聚合酶链反应进行鉴定。为了进行统计分析，细菌计数的数量以对数转换为10为基数。结果：来自56名中位年龄为88（62-98）岁的参与者的数据可用于分析。连翘的对数转换细菌计数，但不是牙龈卟啉单胞菌或丁香单胞菌，与老年居民的发烧有关。Kaplan-Meier方法显示，<104的连翘衣组的累积发热发生率明显低于≥104的连翘衣组。连翘衣原体≥104的组与发热发作的风险增加相关(风险比，3.7；98%置信区间，1.3−10.2；p=0.012)，针对可能的混杂因素进行了调整。结论：在老年疗养院居民中，口腔中连翘菌的细菌负担与发烧的风险有关。
