Abstract：
Air pollutants as risk factors for benign brain tumor (BBT) remain unclear. Therefore, we conducted a nationwide retrospective cohort study by integrating the patients\' clinical data and daily air quality data to assess the environmental risk factors of BBT in Taiwan.Daily air quality data were categorized into quartiles (Q1 to Q4). The adjusted hazard ratio (aHR) was evaluated by comparing the BBT incidence rate of the subjects in Q2-Q4 with that of the subjects in Q1 (the lowest concentration of air pollutants). A total of 161,213 subjects were enrolled in the study. Among the air pollutants tested, the aHR of BBT was significantly higher in the subjects who were exposed to the highest level (Q4) of CO (aHR 1.37, 95% CI 1.08-1.74), NO2 (aHR 1.40, 95% CI 1.09-1.78), and PM2.5 (aHR 1.30, 95% CI 1.02-1.65) than that in the subjects who were exposed to the lowest level (Q1). No significant risk association of BBT with SO2 and PM10 exposure was observed. The results revealed that long-term exposure to air pollutants, particularly CO, NO2, and PM2.5, is associated with the risk of BBT.
摘要：
空气污染物作为良性脑肿瘤（BBT）的危险因素尚不清楚。因此,我们进行了一项全国性的回顾性队列研究,将患者的临床数据和每日空气质量数据进行整合,以评估台湾BBT的环境危险因素.每日空气质量数据分为四分位数（Q1至Q4）。通过比较Q2-Q4受试者的BBT发生率与Q1（空气污染物的最低浓度）受试者的BBT发生率来评估调整后的危险比（aHR）。共有161,213名受试者参加了该研究。在测试的空气污染物中，在暴露于最高CO水平（Q4）的受试者中，BBT的aHR显着较高（aHR1.37，95％CI1.08-1.74），NO2（AHR1.40，95%CI1.09-1.78），和PM2.5（aHR1.30，95%CI1.02-1.65）比暴露于最低水平的受试者（Q1）。未观察到BBT与SO2和PM10暴露的显着风险关联。结果表明，长期接触空气污染物，特别是CO，NO2和PM2.5与BBT的风险相关。
