Abstract：
A meta-analysis was performed to assess the effect of surgical site wound infections and risk factors in neonates undergoing surgery. A systematic literature search up to January 2022 incorporated 17 trials involving 645 neonates who underwent surgery at the beginning of the trial; 198 of them had surgical site wound infections, and 447 were control for neonates. The statistical tools like the dichotomous or continuous method used within a random or fixed-influence model to establish the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the risk factors and influence of surgical site wound infections in neonates undergoing surgery. Surgical site wound infections had significantly higher mortality with OR value 2.03 at 95% CI 1.40-2.95 with P-value <0.001, the longer length of hospital stay (MD, 31.88; 95% CI, 18.17-45.59, P < 0.001), and lower birthweight of neonates (MD, -0.30; 95% CI, -0.53 to -0.07, P = 0.01) compared with neonates with no surgical site wound infections undergoing surgery. However, no remarkable change was observed with surgical site wound infections in the gestational age at birth of neonates (MD, -0.70; 95% CI, -1.46 to 0.05, P = 0.07), and the preoperative antibiotic prophylaxis (OR, 1.28; 95% CI, 0.57-2.87, P = 0.55) compared with no surgical site wound infections for neonates undergoing surgery. Surgical site wound infections had significantly higher mortality, a longer length of hospital stay, and lower birthweight of neonates. However, they had no statistically significant difference in the gestational age at birth of neonates and the preoperative antibiotic prophylaxis compared with no surgical site wound infections for neonates undergoing surgery. Furthermore, evidence is needed to confirm the outcomes.
摘要：
进行了一项荟萃分析，以评估手术部位伤口感染对接受手术的新生儿的影响和危险因素。截至2022年1月的系统文献检索纳入了17项试验，涉及645名在试验开始时接受手术的新生儿;其中198名患有手术部位伤口感染，447例新生儿为对照。在随机或固定影响模型中使用的统计工具，例如二分法或连续法，以建立具有95％置信区间（CI）的优势比（OR）和平均差（MD），以评估手术部位伤口感染的危险因素和影响在接受手术的新生儿中。手术部位伤口感染的死亡率明显更高，在95％CI1.40-2.95时的OR值2.03，P值<0.001，住院时间越长（MD，31.88；95%CI，18.17-45.59，P<0.001），和新生儿出生体重较低(MD，-0.30；95％CI，-0.53至-0.07，P=0.01）与未接受手术部位伤口感染的新生儿相比。然而,在新生儿出生时胎龄的手术部位伤口感染没有观察到显着变化（MD，-0.70；95%CI，-1.46至0.05，P=0.07），和术前抗生素预防(OR，1.28；95%CI，0.57-2.87，P=0.55）与无手术部位伤口感染的新生儿相比。手术部位伤口感染的死亡率明显较高，住院时间较长,和低出生体重的新生儿。然而,对于接受手术的新生儿,与无手术部位伤口感染的新生儿相比,他们在新生儿出生时的胎龄和术前抗生素预防方面无统计学差异.此外，需要证据来确认结果。
