PDF(Pubmed)
Abstract：
Cold agglutinin disease (CAD) is a type of hemolytic anemia in which cold agglutinins can cause agglutination of red blood cells in cold parts of the body and hemolytic anemia. Cold agglutinin-mediated hemolytic anemia can occur in the setting of an underlying viral infection, autoimmune disorder, or lymphoid malignancy, referred to as a secondary cold agglutinin syndrome, or without one of these underlying disorders, referred to as primary CAD (also known as idiopathic CAD). We present a case of a 71-year-old female with hemolytic anemia due to primary CAD. The secondary causes of CAD, including infections, autoimmune disorders, and malignancy, were ruled out. She was successfully treated with prednisone.
摘要：
冷凝集素病（CAD）是一种溶血性贫血，其中冷凝集素可导致身体寒冷部位的红细胞凝集和溶血性贫血。冷凝集素介导的溶血性贫血可以发生在潜在的病毒感染的背景下，自身免疫性疾病，或者淋巴恶性肿瘤,被称为继发性冷凝集素综合征，或者没有这些潜在的疾病，称为原发性CAD（也称为特发性CAD）。我们介绍了一例71岁女性因原发性CAD而出现溶血性贫血的病例。CAD的次要原因，包括感染,自身免疫性疾病，和恶性肿瘤，被排除了。她用泼尼松成功治疗。
