PDF(Pubmed)
Abstract：
Exposure to persistent environmental organic pollutants may contribute to the development of obesity among children. Chlordecone is a persistent organochlorine insecticide with estrogenic properties that was used in the French West Indies (1973-1993) and is still present in the soil and the water and food consumed by the local population. We studied the association between prenatal and childhood exposure to chlordecone and the adiposity of prepubertal children.
Within the Timoun Mother-Child Cohort Study in Guadeloupe (French West Indies), 575 children had a medical examination at seven years of age, including adiposity measurements. A Structural Equation Modeling approach was used to create a global adiposity score from four adiposity indicators: the BMI z-score, percentage of fat mass, sum of the tricipital and subscapular skinfold thickness, and waist-to-height ratio. Chlordecone concentrations were measured in cord blood at birth and in the children\'s blood at seven years of age. Models were adjusted for prenatal and postnatal covariates. Sensitivity analyses accounted for co-exposure to PCB-153 and pp\'-DDE. Mediation analyses, including intermediate birth outcomes, were conducted.
Prenatal chlordecone exposure tended to be associated with increased adiposity at seven years of age, particularly in boys. However, statistical significance was only reached in the third quartile of exposure and neither linear nor non-linear trends could be formally identified. Consideration of preterm birth or birth weight in mediation analyses did not modify the results, as adjustment for PCB-153 and pp\'-DDE co-exposures.
Globally, we found little evidence of an association between chlordecone exposure during the critical in utero or childhood periods of development and altered body-weight homeostasis in childhood. Nevertheless, some associations we observed at seven years of age, although non-significant, were consistent with those observed at earlier ages and would be worth investing during further follow-ups of children of the Timoun Mother-Child Cohort Study when they reach puberty.
Within the Timoun Mother-Child Cohort Study in Guadeloupe (French West Indies), 575 children had a medical examination at seven years of age, including adiposity measurements. A Structural Equation Modeling approach was used to create a global adiposity score from four adiposity indicators: the BMI z-score, percentage of fat mass, sum of the tricipital and subscapular skinfold thickness, and waist-to-height ratio. Chlordecone concentrations were measured in cord blood at birth and in the children\'s blood at seven years of age. Models were adjusted for prenatal and postnatal covariates. Sensitivity analyses accounted for co-exposure to PCB-153 and pp\'-DDE. Mediation analyses, including intermediate birth outcomes, were conducted.
Prenatal chlordecone exposure tended to be associated with increased adiposity at seven years of age, particularly in boys. However, statistical significance was only reached in the third quartile of exposure and neither linear nor non-linear trends could be formally identified. Consideration of preterm birth or birth weight in mediation analyses did not modify the results, as adjustment for PCB-153 and pp\'-DDE co-exposures.
Globally, we found little evidence of an association between chlordecone exposure during the critical in utero or childhood periods of development and altered body-weight homeostasis in childhood. Nevertheless, some associations we observed at seven years of age, although non-significant, were consistent with those observed at earlier ages and would be worth investing during further follow-ups of children of the Timoun Mother-Child Cohort Study when they reach puberty.
摘要：
暴露于持久性环境有机污染物可能导致儿童肥胖的发展。十氯酮是一种持久性有机氯杀虫剂，具有雌激素特性，曾在法属西印度群岛使用（1973-1993年），至今仍存在于土壤以及当地居民消耗的水和食物中。我们研究了产前和儿童期接触十氯酮与青春期前儿童肥胖之间的关系。
在瓜德罗普岛（法属西印度群岛）的Timoun母婴队列研究中，575名儿童在7岁时接受了体检，包括肥胖测量。使用结构方程建模方法从四个肥胖指标创建全局肥胖得分：BMIz得分，脂肪量的百分比，三头肌和肩胛骨下皮褶厚度的总和，腰围和身高比。测量了出生时脐带血和7岁儿童血液中的十氯酮浓度。针对产前和产后协变量调整模型。敏感性分析考虑了PCB-153和pp'-DDE的共同暴露。中介分析,包括中间出生结果，进行了。
在7岁时，产前接触十氯酮往往与肥胖增加有关，尤其是男孩。然而,仅在暴露的第3个四分位数达到统计学意义,并且无法正式确定线性或非线性趋势.在调解分析中考虑早产或出生体重并没有改变结果，作为PCB-153和pp'-DDE共同曝光的调整。
全球,我们发现几乎没有证据表明在子宫内或儿童期发育的关键时期接触十氯酮与儿童期体重稳态改变之间存在关联.然而，我们在七岁时观察到的一些关联，虽然不重要，与早期观察到的结果一致，在Timoun母婴队列研究的儿童进入青春期时的进一步随访中值得投资。
在瓜德罗普岛（法属西印度群岛）的Timoun母婴队列研究中，575名儿童在7岁时接受了体检，包括肥胖测量。使用结构方程建模方法从四个肥胖指标创建全局肥胖得分：BMIz得分，脂肪量的百分比，三头肌和肩胛骨下皮褶厚度的总和，腰围和身高比。测量了出生时脐带血和7岁儿童血液中的十氯酮浓度。针对产前和产后协变量调整模型。敏感性分析考虑了PCB-153和pp'-DDE的共同暴露。中介分析,包括中间出生结果，进行了。
在7岁时，产前接触十氯酮往往与肥胖增加有关，尤其是男孩。然而,仅在暴露的第3个四分位数达到统计学意义,并且无法正式确定线性或非线性趋势.在调解分析中考虑早产或出生体重并没有改变结果，作为PCB-153和pp'-DDE共同曝光的调整。
全球,我们发现几乎没有证据表明在子宫内或儿童期发育的关键时期接触十氯酮与儿童期体重稳态改变之间存在关联.然而，我们在七岁时观察到的一些关联，虽然不重要，与早期观察到的结果一致，在Timoun母婴队列研究的儿童进入青春期时的进一步随访中值得投资。
