Abstract：
Recent evidence indicates that 5-HT1A receptors play a significant role in mediating maternal behavior in rats. Given that they also modulate the mesocortical dopamine system, we hypothesized that 5-HT1A receptors may mediate maternal behavior, possibly by interacting with the D2 receptor. To address this issue, we used a combination of 5-HT1A agonist (8-OH-DPAT, 0.5 mg/kg) and two D2 drugs (an agonist quinpirole, QUIN, 1.0 mg/kg; a potent D2 antagonist haloperidol, HAL, 0.1 mg/kg) on rat maternal behavior in the home-cage maternal behavior and pup preference tests. We replicated the findings that acute QUIN, HAL, and 8-OH-DPAT disrupted home-cage maternal behavior. When administered in combination, pretreatment with HAL and QUIN worsened 8-OH-DPAT-induced maternal disruption and induced a decrease in the pup preference ratio. Accordingly, 8-OH-DPAT enhanced QUIN\' and HAL\'s disruption of pup retrieval and pup preference, reversed the increase in hovering over pups induced by HAL. These findings suggest that activation of 5-HT1A receptors enhances D2-mediated maternal disruption. Furthermore, given that the combination of D2 drugs and 5-HT1A agonists only produced an additive effect on maternal disruption, 5-HT1A receptors may have a direct effect on maternal behavior independent of their interaction with D2 receptors.
摘要：
最近的证据表明，5-HT1A受体在介导大鼠母体行为中起重要作用。鉴于它们还调节中皮层多巴胺系统，我们假设5-HT1A受体可能介导母性行为，可能通过与D2受体相互作用。为了解决这个问题，我们使用了5-HT1A激动剂（8-OH-DPAT，0.5mg/kg）和两种D2药物（激动剂喹吡罗，QUIN,1.0mg/kg；强效D2拮抗剂氟哌啶醇，哈尔,0.1mg/kg）对家笼母体行为和幼犬偏好测试中的大鼠母体行为。我们复制了急性QUIN的发现，哈尔,和8-OH-DPAT破坏了家庭笼子母亲的行为。当联合给药时，用HAL和QUIN预处理会使8-OH-DPAT引起的母体破坏恶化，并导致幼犬偏好率降低。因此，8-OH-DPAT增强了QUIN\'和HAL\'s对幼犬检索和幼犬偏好的干扰，逆转了HAL引起的幼崽悬停增加。这些发现表明5-HT1A受体的激活增强了D2介导的母体破坏。此外，考虑到D2药物和5-HT1A激动剂的组合仅对母体破坏产生累加效应，5-HT1A受体可能对母体行为具有直接影响，而与它们与D2受体的相互作用无关。
