Abstract：
Paraneoplastic neurologic syndromes (PNSs) are a wide spectrum of neurologic diseases characterized by different clinical features, associated with a neoplasia, and triggered by an immune-mediated process. In most cases, it is possible to detect specific neuronal antibodies and the Hu protein is one of the most frequently recognized intracellular antigens in patients with PNSs. Small-cell lung cancer is the most common cancer associated with PNSs, followed by urological, gynecological and hematological malignancies. Otherwise, extra-pulmonary small-cell carcinomas, including Merkel cell carcinoma (MCC), have been rarely described as related to PNSs. In this article we report, for the first time in the published literature, a case of anti-Hu antibody-related subacute sensory neuronopathy in association with MCC.
摘要：
副肿瘤性神经综合征（PNS）是一种广泛的神经系统疾病，具有不同的临床特征。与瘤形成有关，并由免疫介导的过程触发。在大多数情况下,可以检测特定的神经元抗体，并且Hu蛋白是PNS患者中最常识别的细胞内抗原之一。小细胞肺癌是最常见的与PNS相关的癌症，其次是泌尿科，妇科和血液系统恶性肿瘤。否则,肺外小细胞癌,包括默克尔细胞癌（MCC），很少被描述为与PNS相关。在这篇文章中，我们报告，在已发表的文献中第一次，一例与MCC相关的抗Hu抗体相关的亚急性感觉神经病。
