Abstract：
Infrapatellar fat pad (IPFP) is regarded as an essential knee tissue involved in osteoarthritis (OA) for its potential structural-related or metabolism-related function. This cross-sectional study aims to identify which part is more related to OA.
Patients with knee OA (n = 53) and healthy controls (n = 54) were prospectively recruited. Based on high-resolution magnetic resonance imaging with a slice thickness of only 0.35 mm, IPFP structural-related parameters (volume and maximal area), metabolism-related parameter (signal), degeneration indicators, and patellar maltracking indicators (patellar translation, patellofemoral angle, and Insall-Salvati ratio) were measured. IPFP volume (maximal area, and signal) was compared between healthy controls and OA patients. The level of significance for all comparisons was set as .05.
OA patients had higher IPFP signal (672.9 ± 136.9 vs 567.3 ± 63.6, p = .009), but no significant difference in IPFP volume or maximal area compared with healthy controls. In healthy controls, IPFP signal was positively associated with age (β = 1.481; 95% CI: 0.286-2.676; p = .018); IPFP maximal area was positively related to Insall-Salvati ratio (β = 0.001; 95% CI: 0.0003-0.0017; p = .039), but not associated with patellar translation and patellofemoral angle. In OA patients, IPFP signal was positively associated with cartilage loss (β = 0.005; 95% CI: 0.003-0.007; p = .013); no correlation between knee pain and IPFP volume or maximal area was observed.
The metabolism-related function of IPFP, which can be reflected by the IPFP signal, might play a more critical role in OA progression than its structural function.
Patients with knee OA (n = 53) and healthy controls (n = 54) were prospectively recruited. Based on high-resolution magnetic resonance imaging with a slice thickness of only 0.35 mm, IPFP structural-related parameters (volume and maximal area), metabolism-related parameter (signal), degeneration indicators, and patellar maltracking indicators (patellar translation, patellofemoral angle, and Insall-Salvati ratio) were measured. IPFP volume (maximal area, and signal) was compared between healthy controls and OA patients. The level of significance for all comparisons was set as .05.
OA patients had higher IPFP signal (672.9 ± 136.9 vs 567.3 ± 63.6, p = .009), but no significant difference in IPFP volume or maximal area compared with healthy controls. In healthy controls, IPFP signal was positively associated with age (β = 1.481; 95% CI: 0.286-2.676; p = .018); IPFP maximal area was positively related to Insall-Salvati ratio (β = 0.001; 95% CI: 0.0003-0.0017; p = .039), but not associated with patellar translation and patellofemoral angle. In OA patients, IPFP signal was positively associated with cartilage loss (β = 0.005; 95% CI: 0.003-0.007; p = .013); no correlation between knee pain and IPFP volume or maximal area was observed.
The metabolism-related function of IPFP, which can be reflected by the IPFP signal, might play a more critical role in OA progression than its structural function.
摘要：
髌下脂肪垫（IPFP）因其潜在的结构相关或代谢相关功能而被认为是参与骨关节炎（OA）的重要膝关节组织。这项横断面研究旨在确定哪一部分与OA更相关。
前瞻性招募膝关节OA患者（n=53）和健康对照（n=54）。基于切片厚度仅为0.35毫米的高分辨率磁共振成像，IPFP结构相关参数（体积和最大面积），代谢相关参数（信号），变性指标，和髌骨跟踪不良指标(髌骨平移，髌股角,和Insall-Salvati比率)进行了测量。IPFP体积(最大面积,和信号）在健康对照和OA患者之间进行比较。所有比较的显著性水平设定为0.05。
OA患者的IPFP信号较高（672.9±136.9vs567.3±63.6，p=.009），但与健康对照组相比，IPFP体积或最大面积没有显着差异。在健康的控制中，IPFP信号与年龄呈正相关(β=1.481;95%CI:0.286-2.676;p=0.018);IPFP最大面积与Insall-Salvati比值呈正相关(β=0.001;95%CI:0.0003-0.0017;p=0.039),但与髌骨平移和髌股角度无关。在OA患者中，IPFP信号与软骨丢失呈正相关(β=0.005;95%CI:0.003-0.007;p=0.013);膝关节疼痛与IPFP体积或最大面积之间没有相关性。
IPFP的代谢相关功能，可以被IPFP信号反射，可能在OA进展中发挥比其结构功能更重要的作用。
前瞻性招募膝关节OA患者（n=53）和健康对照（n=54）。基于切片厚度仅为0.35毫米的高分辨率磁共振成像，IPFP结构相关参数（体积和最大面积），代谢相关参数（信号），变性指标，和髌骨跟踪不良指标(髌骨平移，髌股角,和Insall-Salvati比率)进行了测量。IPFP体积(最大面积,和信号）在健康对照和OA患者之间进行比较。所有比较的显著性水平设定为0.05。
OA患者的IPFP信号较高（672.9±136.9vs567.3±63.6，p=.009），但与健康对照组相比，IPFP体积或最大面积没有显着差异。在健康的控制中，IPFP信号与年龄呈正相关(β=1.481;95%CI:0.286-2.676;p=0.018);IPFP最大面积与Insall-Salvati比值呈正相关(β=0.001;95%CI:0.0003-0.0017;p=0.039),但与髌骨平移和髌股角度无关。在OA患者中，IPFP信号与软骨丢失呈正相关(β=0.005;95%CI:0.003-0.007;p=0.013);膝关节疼痛与IPFP体积或最大面积之间没有相关性。
IPFP的代谢相关功能，可以被IPFP信号反射，可能在OA进展中发挥比其结构功能更重要的作用。
