PDF(Pubmed)
Abstract：
To investigate the association of recurrent corneal erosion (RCE) with sociodemographic factors and associated ocular conditions or systemic diseases.
This nationwide, population-based, retrospective, matched case-controlled study included 98,895 RCE patients, identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 371.42, were selected from the Taiwan National Health Insurance Research Database. The age-, sex-, and index date- matched control group included 98,895 non-RCE control group also selected from the Taiwan Longitudinal Health Insurance Database 2000. Sociodemographic factors and associated ocular conditions or systemic diseases were examined using univariate logistic regression analyses, and continuous variables were analyzed using paired t-test. The odds ratio (OR) of developing RCE were compared using adjusted logistic regression analysis.
Patients with ocular conditions including corneal abrasion, ocular allergic conditions, and corneal dystrophy were more likely to have RCE than the control group (adjusted OR = 63.56, 95% CI = 42.06-96.06, p < 0.0001; adjusted OR = 24.27, 95% CI = 20.51-28.72, p < 0.0001; adjusted OR = 17.10, 95% CI = 5.14-59.93, p < 0.0001, respectively). Patients with systemic diseases such as diabetes mellitus, hyperlipidaemia, and atopy trait have significantly higher ORs for RCE development. Patients residing in either Northern Taiwan or a metropolis city had higher odds of developing RCE; however, there were no significant differences in income or occupation on the probability to develop RCE.
RCE is strongly associated with corneal abrasion, ocular allergic conditions, corneal dystrophy, diabetes mellitus, hyperlipidaemia, and atopy trait.
This nationwide, population-based, retrospective, matched case-controlled study included 98,895 RCE patients, identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 371.42, were selected from the Taiwan National Health Insurance Research Database. The age-, sex-, and index date- matched control group included 98,895 non-RCE control group also selected from the Taiwan Longitudinal Health Insurance Database 2000. Sociodemographic factors and associated ocular conditions or systemic diseases were examined using univariate logistic regression analyses, and continuous variables were analyzed using paired t-test. The odds ratio (OR) of developing RCE were compared using adjusted logistic regression analysis.
Patients with ocular conditions including corneal abrasion, ocular allergic conditions, and corneal dystrophy were more likely to have RCE than the control group (adjusted OR = 63.56, 95% CI = 42.06-96.06, p < 0.0001; adjusted OR = 24.27, 95% CI = 20.51-28.72, p < 0.0001; adjusted OR = 17.10, 95% CI = 5.14-59.93, p < 0.0001, respectively). Patients with systemic diseases such as diabetes mellitus, hyperlipidaemia, and atopy trait have significantly higher ORs for RCE development. Patients residing in either Northern Taiwan or a metropolis city had higher odds of developing RCE; however, there were no significant differences in income or occupation on the probability to develop RCE.
RCE is strongly associated with corneal abrasion, ocular allergic conditions, corneal dystrophy, diabetes mellitus, hyperlipidaemia, and atopy trait.
摘要：
探讨复发性角膜糜烂（RCE）与社会人口统计学因素及相关眼部疾病或全身性疾病的关系。
全国范围内,以人口为基础,回顾性,匹配的病例对照研究包括98,895例RCE患者，由国际疾病分类确定，第九次修订,临床修改(ICD-9-CM)代码371.42,选自台湾国家健康保险研究数据库。年龄-，sex-,与指标数据匹配的对照组包括98,895个非RCE对照组，也是从台湾2000年纵向健康保险数据库中选择的。使用单变量逻辑回归分析检查了社会人口统计学因素和相关的眼部疾病或全身性疾病。和连续变量采用配对t检验进行分析。使用调整逻辑回归分析比较发展中RCE的比值比（OR）。
眼部疾病包括角膜磨损的患者，眼部过敏状况,与对照组相比，角膜营养不良更容易发生RCE（校正OR=63.56，95％CI=42.06-96.06，p<0.0001；校正OR=24.27，95％CI=20.51-28.72，p<0.0001；校正OR=17.10，95％CI=5.14-59.93，p<0.0001）。患有糖尿病等全身性疾病的患者，高脂血症,和特应性性状对RCE发展具有明显较高的OR。居住在台湾北部或大都市的患者发展RCE的几率更高；然而，收入或职业对发展RCE的可能性没有显着差异。
RCE与角膜磨损密切相关，眼部过敏状况,角膜营养不良,糖尿病,高脂血症,和特应性特征。
全国范围内,以人口为基础,回顾性,匹配的病例对照研究包括98,895例RCE患者，由国际疾病分类确定，第九次修订,临床修改(ICD-9-CM)代码371.42,选自台湾国家健康保险研究数据库。年龄-，sex-,与指标数据匹配的对照组包括98,895个非RCE对照组，也是从台湾2000年纵向健康保险数据库中选择的。使用单变量逻辑回归分析检查了社会人口统计学因素和相关的眼部疾病或全身性疾病。和连续变量采用配对t检验进行分析。使用调整逻辑回归分析比较发展中RCE的比值比（OR）。
眼部疾病包括角膜磨损的患者，眼部过敏状况,与对照组相比，角膜营养不良更容易发生RCE（校正OR=63.56，95％CI=42.06-96.06，p<0.0001；校正OR=24.27，95％CI=20.51-28.72，p<0.0001；校正OR=17.10，95％CI=5.14-59.93，p<0.0001）。患有糖尿病等全身性疾病的患者，高脂血症,和特应性性状对RCE发展具有明显较高的OR。居住在台湾北部或大都市的患者发展RCE的几率更高；然而，收入或职业对发展RCE的可能性没有显着差异。
RCE与角膜磨损密切相关，眼部过敏状况,角膜营养不良,糖尿病,高脂血症,和特应性特征。
