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Abstract：
Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.
摘要：
F类清道夫受体成员2（SCARF2）由具有非常大的细胞质结构域的内皮细胞表达，是第二同种型，也称为由内皮细胞2表达的清道夫受体(SREC-2)。SREC-1在各种内源性和外源性配体的结合和内吞作用中起重要作用。已经对修饰的低密度脂蛋白内化活性进行了许多研究，但是对SCARF2的研究很少。已发现SCARF2在胶质母细胞瘤(GBM)中的表达高于正常脑组织。通过对癌症基因组图谱数据库的分析,证实SCARF2在GBM中广泛表达，SCARF2表达增加与胶质瘤患者预后不良相关。本研讨成果显示SCARF2在GBM细胞系和患者中的表达增高，提示SCARF2可能是包括神经胶质瘤在内的癌症的潜在诊断标志物和治疗分子.
