PDF(Pubmed)
Abstract：
UNASSIGNED: Restricted and repetitive behaviors (RRBs) are a core symptom in the diagnosis of autism spectrum disorder (ASD). The complexity of behavioral patterns has called for the creation of phenotypically homogeneous subgroups among individuals with ASD. The purpose of this study was 1) to investigate the different types of RRBs and 2) to explore whether subgroups created by RRBs would show unique levels of functioning in toddlers and young children with ASD.
UNASSIGNED: A total of 313 children with ASD, aged 12-42 months were included in the analysis. The Autism Diagnostic Interview-Revised was used to obtain information on the different types of RRBs by grouping 15 items into six categories. The Vineland Adaptive Behaviors Scale, a parent-reported questionnaire, was used to measure adaptive functioning. A portion of the children were analyzed separately for verbal-related RRBs based on their expressive language level. Two-step cluster analysis using RRB groups as features was used to create subgroups. Analysis of covariance while covarying for age and language was performed to explore the clinical characteristics of each cluster group.
UNASSIGNED: Sensory-related RRBs were the most prevalent, followed by circumscribed interests, interest in objects, resistance to change, and repetitive body movements. A subset of the children was analyzed separately to explore verbal-related RRBs. Four cluster groups were created based on reported RRBs, with multiple RRBs demonstrating significant delays in adaptive functioning.
UNASSIGNED: Heterogeneity of RRBs emerges at a young age. The different patterns of RRBs can be used as valuable information to determine developmental trajectories with better implications for treatment approaches.
UNASSIGNED: A total of 313 children with ASD, aged 12-42 months were included in the analysis. The Autism Diagnostic Interview-Revised was used to obtain information on the different types of RRBs by grouping 15 items into six categories. The Vineland Adaptive Behaviors Scale, a parent-reported questionnaire, was used to measure adaptive functioning. A portion of the children were analyzed separately for verbal-related RRBs based on their expressive language level. Two-step cluster analysis using RRB groups as features was used to create subgroups. Analysis of covariance while covarying for age and language was performed to explore the clinical characteristics of each cluster group.
UNASSIGNED: Sensory-related RRBs were the most prevalent, followed by circumscribed interests, interest in objects, resistance to change, and repetitive body movements. A subset of the children was analyzed separately to explore verbal-related RRBs. Four cluster groups were created based on reported RRBs, with multiple RRBs demonstrating significant delays in adaptive functioning.
UNASSIGNED: Heterogeneity of RRBs emerges at a young age. The different patterns of RRBs can be used as valuable information to determine developmental trajectories with better implications for treatment approaches.
摘要：
非ASSIGNED：限制和重复行为（RRB）是自闭症谱系障碍（ASD）诊断的核心症状。行为模式的复杂性要求在患有ASD的个体中创建表型同质的亚组。这项研究的目的是1）调查不同类型的RRB，2）探索RRB创建的亚组是否会在ASD幼儿和幼儿中显示出独特的功能水平。
UNASSIGNED：总共313名患有ASD的儿童，年龄为12~42个月的纳入分析.自闭症诊断访谈-修订版用于通过将15个项目分为六个类别来获取有关不同类型的RRB的信息。葡萄园适应行为量表，一份家长报告的问卷，用于测量自适应功能。根据部分儿童的表达语言水平，分别分析了与言语相关的RRB。使用RRB组作为特征的两步聚类分析用于创建子组。进行了年龄和语言协方差的协方差分析，以探索每个聚类组的临床特征。
未经批准：与感官相关的RRB是最普遍的，其次是受限制的利益，对物体的兴趣,抵抗变化,和重复的身体动作。分别分析了一部分儿童，以探索与言语相关的RRB。根据报告的RRB创建了四个集群组，多个RRB表现出自适应功能的显著延迟。
未经评估：RRB的异质性在年轻时出现。RRB的不同模式可以用作有价值的信息，以确定对治疗方法具有更好意义的发育轨迹。
UNASSIGNED：总共313名患有ASD的儿童，年龄为12~42个月的纳入分析.自闭症诊断访谈-修订版用于通过将15个项目分为六个类别来获取有关不同类型的RRB的信息。葡萄园适应行为量表，一份家长报告的问卷，用于测量自适应功能。根据部分儿童的表达语言水平，分别分析了与言语相关的RRB。使用RRB组作为特征的两步聚类分析用于创建子组。进行了年龄和语言协方差的协方差分析，以探索每个聚类组的临床特征。
未经批准：与感官相关的RRB是最普遍的，其次是受限制的利益，对物体的兴趣,抵抗变化,和重复的身体动作。分别分析了一部分儿童，以探索与言语相关的RRB。根据报告的RRB创建了四个集群组，多个RRB表现出自适应功能的显著延迟。
未经评估：RRB的异质性在年轻时出现。RRB的不同模式可以用作有价值的信息，以确定对治疗方法具有更好意义的发育轨迹。
