PDF(Pubmed)
Abstract：
A growing body of studies indicate that small noncoding RNAs, especially microRNAs (miRNA), play a crucial role in response to peripheral nerve injuries. During Wallerian degeneration and regeneration processes, they orchestrate several pathways, in particular the MAPK, AKT, and EGR2 (KROX20) pathways. Certain miRNAs show specific expression profiles upon a nerve lesion correlating with the subsequent nerve regeneration stages such as dedifferentiation and with migration of Schwann cells, uptake of debris, neurite outgrowth and finally remyelination of regenerated axons. This review highlights (a) the specific expression profiles of miRNAs upon a nerve lesion and (b) how miRNAs regulate nerve regeneration by acting on distinct pathways and linked proteins. Shedding light on the role of miRNAs associated with peripheral nerve regeneration will help researchers to better understand the molecular mechanisms and deliver targets for precision medicine.
摘要：
越来越多的研究表明，小的非编码RNA，特别是microRNA（miRNA），在周围神经损伤的反应中起着至关重要的作用。在Wallerian变性和再生过程中,他们策划了几条路，特别是MAPK,AKT,和EGR2(KROX20)途径。某些miRNA在与随后的神经再生阶段（如去分化和施万细胞的迁移）相关的神经损伤时显示出特定的表达谱。碎片的吸收，神经突生长，最后再生轴突髓鞘再生。这篇综述强调了（a）神经损伤时miRNA的特定表达谱和（b）miRNA如何通过作用于不同的途径和连接的蛋白质来调节神经再生。阐明与周围神经再生相关的miRNAs的作用将有助于研究人员更好地理解分子机制并为精准医学提供靶标。
