Abstract：
Equine herpesvirus-1 (EHV-1) myeloencephalopathy (EHM) is a devastating consequence of EHV-1 infection that has significant economic consequences. However, clinical EHM is relatively rare and occurs in only approximately 10% of infected horses. While there is a positive correlation between the duration and magnitude of viremia and incidence of EHM, it is likely that a combination of host and viral factors determine whether EHM occurs. The identification of these factors is of high interest for the equine community and has been the topic of much research for vaccine development and to predict which horses might be most at risk for developing EHM. The aim of this review is to highlight host immunity contributions to EHM pathogenesis at different sites of EHV-1 infection to shed light on the different aspects and interdependence of the response to EHV-1 in the time course of infection.
摘要：
马疱疹病毒-1（EHV-1）骨髓脑病（EHM）是EHV-1感染的破坏性后果，具有显着的经济后果。然而,临床EHM相对罕见，仅发生在约10％的受感染马中。虽然病毒血症的持续时间和程度与EHM的发生率之间存在正相关，可能是宿主因子和病毒因子的组合决定了EHM是否发生.这些因素的鉴定对马社区具有很高的兴趣，并且已经成为疫苗开发和预测哪些马可能最容易发展EHM的许多研究的主题。这篇综述的目的是强调在EHV-1感染的不同部位宿主免疫对EHM发病机理的贡献，以阐明在感染时间过程中对EHV-1的反应的不同方面和相互依存关系。
