PDF(Pubmed)
Abstract：
UNASSIGNED: Atrial Epicardial Adipose Tissue (EAT) is presumably involved in the pathogenesis of atrial fibrillation (AF). The transient nature of postoperative AF (POAF) suggests that surgery-induced triggers provoke an unmasking of a pre-existent AF substrate. The aim is to investigate the association between the volume of EAT and the occurrence of POAF. We hypothesise that the likelihood of developing POAF is higher in patients with high compared to low left atrial (LA) EAT volumes.
UNASSIGNED: Quantification of LA EAT based on the Hounsfield Units using custom made software was performed on pre-operative coronary computed tomography angiography scans of patients who underwent cardiac surgery between 2009 and 2019. Patients with mitral valve disease were excluded.
UNASSIGNED: A total of 83 patients were included in this study (CABG = 34, aortic valve = 33, aorta ascendens n = 7, combination n = 9), of which 43 patients developed POAF. The EAT percentage in the LA wall nor indexed EAT volumes differed between patients with POAF and with sinus rhythm (all P > 0.05). In multivariable analysis, age and LA volume index (LAVI) were the only independent predictors for early POAF (OR: 1.076 and 1.056, respectively).
UNASSIGNED: As expected, advanced age and LAVI were independent predictors of POAF. However, the amount of local EAT was not associated with the occurrence of AF after cardiac surgery. This suggests that the role of EAT in POAF is rather limited, or that the association of EAT in the early phase of POAF is obscured by the dominance of surgical-induced triggers.
UNASSIGNED: Quantification of LA EAT based on the Hounsfield Units using custom made software was performed on pre-operative coronary computed tomography angiography scans of patients who underwent cardiac surgery between 2009 and 2019. Patients with mitral valve disease were excluded.
UNASSIGNED: A total of 83 patients were included in this study (CABG = 34, aortic valve = 33, aorta ascendens n = 7, combination n = 9), of which 43 patients developed POAF. The EAT percentage in the LA wall nor indexed EAT volumes differed between patients with POAF and with sinus rhythm (all P > 0.05). In multivariable analysis, age and LA volume index (LAVI) were the only independent predictors for early POAF (OR: 1.076 and 1.056, respectively).
UNASSIGNED: As expected, advanced age and LAVI were independent predictors of POAF. However, the amount of local EAT was not associated with the occurrence of AF after cardiac surgery. This suggests that the role of EAT in POAF is rather limited, or that the association of EAT in the early phase of POAF is obscured by the dominance of surgical-induced triggers.
摘要：
未经证实：心房心外膜脂肪组织(EAT)可能与心房颤动(AF)的发病机制有关。术后AF（POAF）的短暂性表明，手术诱发的触发因素会引起先前存在的AF基质的掩蔽。目的是研究EAT量与POAF发生之间的关系。我们假设，与左心房（LA）低EAT量相比，高患者发生POAF的可能性更高。
UNASSIGNED：在2009年至2019年期间接受心脏手术的患者的术前冠状动脉计算机断层扫描血管造影扫描中，使用定制软件对基于Hounsfield单位的LAEAT进行定量。排除患有二尖瓣疾病的患者。
未经证实：本研究共纳入83例患者（CABG=34，主动脉瓣=33，主动脉上升n=7，组合n=9），其中43例患者发生POAF。在POAF患者和窦性心律患者之间，LA壁的EAT百分比或指数EAT体积存在差异（均P>0.05）。在多变量分析中，年龄和LA体积指数(LAVI)是早期POAF的唯一独立预测因子(OR分别为1.076和1.056).
未经评估：如预期，高龄和LAVI是POAF的独立预测因子.然而,局部EAT的量与心脏手术后房颤的发生无关.这表明EAT在POAF中的作用相当有限，或者POAF早期EAT的关联被手术诱导的触发因素的优势所掩盖。
UNASSIGNED：在2009年至2019年期间接受心脏手术的患者的术前冠状动脉计算机断层扫描血管造影扫描中，使用定制软件对基于Hounsfield单位的LAEAT进行定量。排除患有二尖瓣疾病的患者。
未经证实：本研究共纳入83例患者（CABG=34，主动脉瓣=33，主动脉上升n=7，组合n=9），其中43例患者发生POAF。在POAF患者和窦性心律患者之间，LA壁的EAT百分比或指数EAT体积存在差异（均P>0.05）。在多变量分析中，年龄和LA体积指数(LAVI)是早期POAF的唯一独立预测因子(OR分别为1.076和1.056).
未经评估：如预期，高龄和LAVI是POAF的独立预测因子.然而,局部EAT的量与心脏手术后房颤的发生无关.这表明EAT在POAF中的作用相当有限，或者POAF早期EAT的关联被手术诱导的触发因素的优势所掩盖。
