PDF(Pubmed)
Abstract：
As a member of the tumor necrosis factor receptor superfamily (TNFRSF), death receptor 6 (DR6) has a similar structural architecture to other family members. The extracellular region of DR6 contains four cysteine-rich domains, followed by a single-pass transmembrane domain and an intracellular region. Since its discovery, DR6 has become an orphan receptor ubiquitously expressed to transduce unique signaling pathways. Although the free ectodomains of β-amyloid precursor protein (APP) can bind to DR6 to induce apoptotic signals, the natural ligands of DR6 still remain largely unknown. In this review, we focus on recent research progress of structural and functional studies on DR6 for better understanding DR6-mediated signaling and the treatment of DR6-related diseases.
摘要：
作为肿瘤坏死因子受体超家族（TNFRSF）的成员，死亡受体6（DR6）具有与其他家族成员相似的结构。DR6的胞外区包含四个富含半胱氨酸的结构域，其次是一个单程跨膜结构域和细胞内区域。自从它被发现,DR6已成为广泛表达以转导独特信号通路的孤儿受体。尽管β-淀粉样前体蛋白（APP）的游离胞外域可以与DR6结合以诱导凋亡信号，DR6的天然配体仍然很大程度上未知。在这次审查中,我们关注DR6的结构和功能研究的最新进展,以更好地了解DR6介导的信号传导和DR6相关疾病的治疗.
