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Abstract：
UNASSIGNED: Several recent studies have stated that glycyrrhizin and licorice extract are present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China. Significant data are showing that glycyrrhizin and licorice extract have multiple beneficial activities in combating most features of SARS-CoV-2.
UNASSIGNED: The aim of current review was to highlight recent progresses in research that showed the evidence of the potential use of glycyrrhizin and licorice extract against COVID-19.
UNASSIGNED: We have reviewed the information published from 1979 to October 2020. These studies demonstrated the effects , use and safety of glycyrrhizin and icorice extract against viral infections,bacterial infections, inflammatory disorders of lung ( in vitro and in vivo). These studies were collated through online electronic databases research (Academic libraries as PubMed, Scopus, Web of Science and Egyptian Knowledge Bank).
UNASSIGNED: Pooled effect size of articles provides information about the rationale for using glycyrrhizin and licorice extract to treat COVID-19. Fifty studies demonstrate antiviral activity of glycyrrhizin and licorice extract. The most frequent mechanism of the antiviral activity is due to disrupting viral uptake into the host cells and disrupting the interaction between receptor- binding domain (RBD) of SARS-COV2 and ACE2 in recent articles. Fifty studies indicate that glycyrrhizin and licorice extract have significant antioxidant, anti-inflammatory and immunomodulatory effects. Twenty five studies provide evidence for the protective effect of glycyrrhizin and licorice extract against inflammation-induced acute lung injury and cardiovascular disorders.
UNASSIGNED: The current study showed several evidence regarding the beneficial effects of glycyrrhizin and licorice extract in combating COVID-19. More randomized clinical trials are needed to obtain a precise conclusion.
UNASSIGNED: The aim of current review was to highlight recent progresses in research that showed the evidence of the potential use of glycyrrhizin and licorice extract against COVID-19.
UNASSIGNED: We have reviewed the information published from 1979 to October 2020. These studies demonstrated the effects , use and safety of glycyrrhizin and icorice extract against viral infections,bacterial infections, inflammatory disorders of lung ( in vitro and in vivo). These studies were collated through online electronic databases research (Academic libraries as PubMed, Scopus, Web of Science and Egyptian Knowledge Bank).
UNASSIGNED: Pooled effect size of articles provides information about the rationale for using glycyrrhizin and licorice extract to treat COVID-19. Fifty studies demonstrate antiviral activity of glycyrrhizin and licorice extract. The most frequent mechanism of the antiviral activity is due to disrupting viral uptake into the host cells and disrupting the interaction between receptor- binding domain (RBD) of SARS-COV2 and ACE2 in recent articles. Fifty studies indicate that glycyrrhizin and licorice extract have significant antioxidant, anti-inflammatory and immunomodulatory effects. Twenty five studies provide evidence for the protective effect of glycyrrhizin and licorice extract against inflammation-induced acute lung injury and cardiovascular disorders.
UNASSIGNED: The current study showed several evidence regarding the beneficial effects of glycyrrhizin and licorice extract in combating COVID-19. More randomized clinical trials are needed to obtain a precise conclusion.
摘要：
UNASSIGNED：最近的几项研究表明，甘草甜素和甘草提取物存在于中国大多数抗SARS-CoV-2的传统中药配方中。重要数据显示甘草甜素和甘草提取物在对抗SARS-CoV-2的大多数特征方面具有多种有益活性。
UNASSIGNED：本综述的目的是强调最近的研究进展，这些研究进展表明甘草甜素和甘草提取物可能用于对抗COVID-19。
UNASSIGNED：我们审查了1979年至2020年10月发布的信息。这些研究证明了这些影响，甘草甜素和icorice提取物对病毒感染的使用和安全性，细菌感染,肺部炎症性疾病（体外和体内）。这些研究是通过在线电子数据库研究(学术图书馆作为PubMed，Scopus,WebofScience和埃及知识库)。
未经评估：文章的集合效应大小提供了有关使用甘草酸和甘草提取物治疗COVID-19的基本原理的信息。50项研究证明了甘草酸和甘草提取物的抗病毒活性。在最近的文章中,抗病毒活性的最常见机制是由于破坏病毒摄取到宿主细胞中并破坏SARS-COV2的受体结合域(RBD)与ACE2之间的相互作用。50项研究表明，甘草酸和甘草提取物具有显著的抗氧化作用，抗炎和免疫调节作用。25项研究为甘草酸和甘草提取物对炎症诱导的急性肺损伤和心血管疾病的保护作用提供了证据。
未经证实：目前的研究显示了一些关于甘草酸和甘草提取物在对抗COVID-19中的有益作用的证据。需要更多的随机临床试验来获得准确的结论。
UNASSIGNED：本综述的目的是强调最近的研究进展，这些研究进展表明甘草甜素和甘草提取物可能用于对抗COVID-19。
UNASSIGNED：我们审查了1979年至2020年10月发布的信息。这些研究证明了这些影响，甘草甜素和icorice提取物对病毒感染的使用和安全性，细菌感染,肺部炎症性疾病（体外和体内）。这些研究是通过在线电子数据库研究(学术图书馆作为PubMed，Scopus,WebofScience和埃及知识库)。
未经评估：文章的集合效应大小提供了有关使用甘草酸和甘草提取物治疗COVID-19的基本原理的信息。50项研究证明了甘草酸和甘草提取物的抗病毒活性。在最近的文章中,抗病毒活性的最常见机制是由于破坏病毒摄取到宿主细胞中并破坏SARS-COV2的受体结合域(RBD)与ACE2之间的相互作用。50项研究表明，甘草酸和甘草提取物具有显著的抗氧化作用，抗炎和免疫调节作用。25项研究为甘草酸和甘草提取物对炎症诱导的急性肺损伤和心血管疾病的保护作用提供了证据。
未经证实：目前的研究显示了一些关于甘草酸和甘草提取物在对抗COVID-19中的有益作用的证据。需要更多的随机临床试验来获得准确的结论。
