Abstract：
Cell migration is necessary for morphogenesis, tissue homeostasis, wound healing and immune response. It is also involved in diseases. In particular, cell migration is inherent in metastasis. Cells can migrate individually or in groups. To migrate efficiently, cells need to be able to organize into a leading front that protrudes by forming membrane extensions and a trailing edge that contracts. This organization is scaled up at the group level during collective cell movements. If a cell or a group of cells is unable to limit its leading edge and hence to restrict the formation of protrusions to the front, directional movements are impaired or abrogated. Here we summarize our current understanding of the mechanisms restricting protrusion formation in collective cell migration. We focus on three in vivo examples: the neural crest cell migration, the rotatory migration of follicle cells around the Drosophila egg chamber and the border cell migration during oogenesis.
摘要：
细胞迁移是形态发生所必需的,组织稳态，伤口愈合和免疫反应。它也与疾病有关。特别是,细胞迁移是转移固有的。细胞可以单独或成组迁移。要高效迁移，细胞需要能够组织成通过形成膜延伸而突出的前前缘和收缩的后缘。在集体细胞运动期间，该组织在小组一级扩大。如果一个单元或一组单元不能限制其前缘，从而限制前部突起的形成，定向运动受损或被废除。在这里，我们总结了我们目前对集体细胞迁移中限制突起形成的机制的理解。我们集中在三个体内例子：神经c细胞迁移，果蝇卵室周围卵泡细胞的旋转迁移和卵子发生过程中的边界细胞迁移。
