PDF(Pubmed)
Abstract：
Metformin is a widely accepted first-line hypoglycemic agent in current clinical practice, and it has been applied to the clinic for more than 60 years. Recently, researchers have identified that metformin not only has an efficient capacity to lower glucose but also exerts anti-aging effects by regulating intracellular signaling molecules. With the accelerating aging process and mankind\'s desire for a long and healthy life, studies on aging have witnessed an unprecedented boom. Osteoporosis, sarcopenia, degenerative osteoarthropathy, and frailty are age-related diseases of the musculoskeletal system. The decline in motor function is a problem that many elderly people have to face, and in serious cases, they may even fail to self-care, and their quality of life will be seriously reduced. Therefore, exploring potential treatments to effectively prevent or delay the progression of aging-related diseases is essential to promote healthy aging. In this review, we first briefly describe the origin of metformin and the aging of the movement system, and next review the evidence associated with its ability to extend lifespan. Furthermore, we discuss the mechanisms related to the modulation of aging in the musculoskeletal system by metformin, mainly its contribution to bone homeostasis, muscle aging, and joint degeneration. Finally, we analyze the protective benefits of metformin in aging-related diseases of the musculoskeletal system.
摘要：
二甲双胍是目前临床实践中被广泛接受的一线降血糖药,它已经应用于临床超过60年。最近,研究人员发现,二甲双胍不仅具有有效的降糖能力,而且通过调节细胞内信号分子发挥抗衰老作用.随着老龄化进程的加快和人类对长寿和健康生活的渴望,关于衰老的研究见证了前所未有的繁荣。骨质疏松,少肌症,退行性骨关节病，和虚弱是肌肉骨骼系统的年龄相关疾病。运动功能下降是许多老年人不得不面对的问题,在严重的情况下，他们甚至可能无法自我照顾，他们的生活质量将严重下降。因此,探索有效预防或延缓衰老相关疾病进展的潜在治疗方法对促进健康衰老至关重要。在这次审查中,我们首先简述二甲双胍的起源和运动系统的老化,接下来回顾与它延长寿命的能力相关的证据。此外，我们讨论了二甲双胍调节肌肉骨骼系统衰老的相关机制，主要是它对骨骼稳态的贡献，肌肉老化，和关节退化。最后,我们分析了二甲双胍对肌肉骨骼系统衰老相关疾病的保护作用.
