Abstract：
Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing significant damage to the basement membrane of the skin, resulting in marked pruritus and blisters on the abdomen and extremities. Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies and histopathology of a skin biopsy. Treatment, just as for other autoimmune dermatoses, is achieved by corticosteroids with the risk of relapses in subsequent pregnancies. Fetal growth restriction and pre-maturity are potential fetal complications associated with the disease, hence the recommended combined antenatal care by a dermatologist as well as an obstetrician, however, this disease is unlikely to be a source of significant maternal morbidity or mortality.
摘要：
类天疱疮妊娠（PG），也被称为妊娠期类天疱疮，因为它与怀孕事件特别相关，是罕见的妊娠相关皮肤病之一，以抗大疱性类天疱疮抗原180和230（BP180和BP230）的自身抗体形成为特征，对皮肤的基底膜造成严重损害，导致腹部和四肢出现明显的瘙痒和水疱。PG的诊断基本上是通过特征性的临床表现，并通过免疫荧光研究和皮肤活检的组织病理学证实。治疗,就像其他自身免疫性皮肤病一样，是通过皮质类固醇实现的，在随后的怀孕中有复发的风险。胎儿生长受限和早产是与该疾病相关的潜在胎儿并发症，因此，皮肤科医生和产科医生推荐的联合产前护理，然而,这种疾病不可能是显著的孕产妇发病率或死亡率的来源.
