Abstract：
A 2.5-year-old castrated male cat presented with fever and marked generalized lymphadenopathy of 4-months duration, despite treatment with amoxicillin-clavulanate/marbofloxacin. Abnormalities were not detected on complete blood count, serum chemistry, and FIV/FeLV test apart from a borderline, non-regenerative anemia. Peripheral lymph node fine needle aspirations revealed a marked increase in the percentage of intermediate- and lymphoblastic-lymphocytes in addition to reactive macrophages. Three weeks after presentation, the cat developed a severe, regenerative, immune-mediated hemolytic anemia (IMHA) which responded to immunosuppressive therapy. Fever and lymphadenopathy persisted. Peripheral lymph nodes tested positive for Bartonella henselae DNA in real-time PCR assay and sequencing. Treatment with pradofloxacin and doxycycline resulted in resolution of clinical signs, and negative PCR tests. Despite its reported low pathogenicity, B. henselae infection should also be considered in cats with protracted unexplained fever, lymphadenitis, and IMHA. Furthermore, a combination of pradofloxacin and doxycycline might be considered in cats with bartonellosis given its apparent clinical efficacy.
摘要：
一只2.5岁的cast割雄性猫出现发烧和明显的全身淋巴结肿大，持续时间为4个月，尽管用阿莫西林-克拉维酸/马波沙星治疗。全血细胞计数没有检测到异常，血清化学,和FIV/FeLV测试，除了边界线，非再生性贫血。外周淋巴结细针穿刺显示，除反应性巨噬细胞外，中间淋巴细胞和淋巴母细胞淋巴细胞的百分比显着增加。陈述后三周，猫患上了严重的，再生，免疫介导的溶血性贫血（IMHA）对免疫抑制治疗有反应。发热和淋巴结病持续存在。在实时PCR测定和测序中，外周淋巴结检测出汉氏巴尔通体DNA阳性。使用普拉氧氟沙星和多西环素治疗可缓解临床症状，和阴性的PCR测试。尽管据报道其致病性低，B.henselae感染也应考虑在猫与长期不明原因的发烧，淋巴结炎,IMHA。此外，鉴于其明显的临床疗效，在患有巴顿病的猫中可以考虑使用普拉氧氟沙星和多西环素的组合。
