Abstract：
Long non-coding RNAs (lncRNAs) are a class of non-coding RNA with a length greater than 200 nt. It has a mRNA-like structure, formed by splicing after transcription, and contains a polyA tail and a promoter, of whom promoter plays a role by binding transcription factors. LncRNAs\' sequences are low in conservation, and other species can only find a handful of the same lncRNAs as humans, and there are different splicing ways during the differentiation of identical species, with spatiotemporal expression specificity. With developing high-throughput sequencing and bioinformatics, found that more and more lncRNAs associated with nervous system disease. This article deals with the regulation of certain lncRNAs in the nervous system disease, by mean of to understand its mechanism of action, and the pathogenesis of some neurological diseases have a fresh understanding, deposit a foundation for resulting research and clinical treatment of disease.
摘要：
长链非编码RNA(lncRNA)是一类长度大于200nt的非编码RNA。它有类似mRNA的结构,通过转录后的剪接形成，含有polyA尾和启动子,其中启动子通过结合转录因子发挥作用。LncRNAs序列保守性低，其他物种只能找到少数与人类相同的lncRNAs，在同一物种的分化过程中有不同的剪接方式，具有时空表达特异性。随着高通量测序和生物信息学的发展，发现越来越多的lncRNAs与神经系统疾病相关。本文涉及神经系统疾病中某些lncRNAs的调节，为了理解它的作用机制，对一些神经系统疾病的发病机制有了新的认识，为疾病的研究和临床治疗奠定了基础。
